The most recommended mutation books

I will admit I came to this book for the author. David Koepp is a renowned screenwriter whose credits include Jurassic Park and Mission: Impossible, among many others. Screenwriters have to work within the confines of a 120-page format, so it’s no wonder that this novel moves at a lightning pace. I love that it features a deadly fungal organism that could end humanity, but the story is really about the three people desperately trying to contain it. 

Mirabile is a collection of linked short stories about a group of humans who have traveled to a distant planet and established a colony there.

They’ve brought seeds and plants from Earth designed to mutate and adapt to on-the-ground conditions… but some of them mutate a lot! Annie “Jason” Masmajean is a middle-aged “Jason,” a scientist who hunts harmful mutations, and her story is beautifully told.

She’s a terrific, funny protagonist, navigating her world with her growing chosen family and the communities around them. It’s unique in that it’s a book about solving problems, not about conquering a new world.

The writing is terrific, and the characters are very memorable. It is highly recommended!

Call me weird. I’m not a fan of series books. Unless, that is, they’re written by Nicholas Sansbury Smith. The problem with a book series for me is that I get bored of the same idea book after book after…zzzzzz. But when someone writing a book series is constantly bringing new ideas to the table, it keeps me reading. Couple that with characters we care about, and a heavy focus on moving the plot forward, and I’ll finish a book in no time and be eager to read the next one. This, my friends, is the first book in one of those series. 

I have the 1971 paperback printing of More Than Human, with the Robert Pepper cover art. The book has a special significance for me; although unrelated in plot, it has similarities to my book: it is science fiction, has an unusual structure, a complex timeline, deals with psychology, and features investigation and discovery. The fact that it was written in 1953, before the Internet, Earth satellites, personal computers, and cell phones, facilitates the reader’s attention to the rather complex story. Seven individuals, Lone, Janie, twins Bonnie and Beanie, Baby, Gerry, and Hip, are exemplars of inequality, with peculiar capabilities and shortcomings. The German word gestalt, meaning the forming of a pattern, describes how, together, they embody the next step in human evolution.

This book starts and ends with the story of Dr. Jiankui He, the infamous Chinese researcher responsible for the first CRISPR experiment resulting in genetically modified children.

It chronicles Dr. He’s “meteoric rise to fame” followed by his “dramatic fall from grace.”

In telling this story Kirksey, a cultural anthropologist, entertains the reader with details about interesting characters he meets and places he visits in his quest to both situate this debacle in relation to earlier efforts at genetic engineering and cell therapy in the United States and to confirm some of the contested details about what did or did not happen in China in the years leading up to this “first”.

Along the way, Kirksey lays bare salient facts about conflicts of interests among scientists, the corporate world’s vaunted pursuit of profit, and the ways in which nationalistic aspirations seed unhealthy competition.

I find it scary that pandemics and viral mutations are becoming more likely than ever.

In this book, a Doomsday Germ has mutated to the point that it is resistant to all known antibiotics, and as a former biomedical researcher, nothing is more frightening to me than knowing that deadly microbes unleashed on mankind are not only possible but probable.

I really like that the author, a physician who knows a thing or two about epidemics and the danger of antibiotic resistance, was adept at bringing me along for the ride, explaining what’s possible with today’s medical advances and the real dangers of crossing the line.

It’s a powerful update on Noble’s book, zooming in on the workings of the biomolecular circuits surrounding the DNA.

Some of the circuits are studied in great detail, looking closely at how they work, and at how they evolve in response to mutations in the DNA. A disadvantageous mutation is eliminated by natural selection. But as well as advantageous mutations it turns out that ‘neutral’ mutations, conferring no immediate advantage, are important and indeed crucial. That resolved one of the dichotomized disputes noted in Wills’ book.

The Chrysalids – my inaugural dive into science fiction in the late sixties – hooked me from the first paragraph.

Wyndham creates a dystopian world of post-nuclear destruction where genetic mutations abound, and if discovered, culled from a civilization steeped in a stark biblical ideology. The Chrysalids track protagonist David Strorm as he safeguards his six-toed friend, Sophie, and ultimately connects with a band of telepaths offering new world hope.

I loved this book because of its adolescent hero and his defiance against a society that was morally corrupt. 

When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.

The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.

Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative. 

At the other extreme from Contact, Greg Benford’s COSM involves very small wormholes. Or at least, a wormhole that starts out small. In his variation on the theme, an experiment on Earth accidentally opens a wormhole which in effect creates a new universe, which the experimenters can study and eventually communicate with through the wormhole. Again, real science, but technology a little (this time only a little!) beyond our present capabilities. And it raises the intriguing question of whether our Universe might have been made in this way by a race of superior beings (gods?) in another universe.