100 books like The Mutant Project

A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).

The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.

Somewhat paradoxically, this treatise against genetic enhancement starts with the case of a deaf couple who want to have a deaf child.

This is a case I often discuss in exploring the difference between disease, disability, and diversity. Following on from this case description, Sandel asks, “Is it wrong to make a child deaf by design?” And what if the desired trait was not deafness but height, athletic prowess, health, or intelligence, and the aim was to gain a competitive advantage?

Would your answer be the same? In the pages that follow, Sandel builds a case against “reengineering our nature” grounded in an ethic of giftedness (i.e., a reverence for life as a gift).

He eschews the drive to mastery and insists that “[t]o appreciate children as gifts is to accept them as they come, not as objects of our design, or products of our will, or instruments of our… show more.

This work of fiction highlights the potential dangers of genetic engineering.

It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.

In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.

Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer. 

Many assert that “science is outpacing ethics.”

In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”

In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.

He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.

When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.

The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.

Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative. 

I originally picked up this book because I really like the author. Seanan McGuire never disappoints. Parasite is part one of a series, and is a completely fresh take on what some people might call zombies (although there is a lot of room for speculation there). The characters were compelling, and the plot kept me reading when I should have been doing countless other things. I love everything I’ve ever read by McGuire (alternate pen name Mira Grant), and this book was no different.

I thoroughly enjoyed reading James Patterson’s and Neil McMahon’s Toys.

Patterson doesn’t delve into science fiction often, but when he does, thought-provoking ideas are present that question the social consequences of those imaginary worlds. In Toys, Genetic Elites rule and ordinary humans being the subjugated class.

The Elite Agent of Change, Baker, thinks he’s an Elite only to learn that he’s an ordinary human. He searches for his true origins while being hunted by the very Elites he protected from ordinary humans.

This novel is even more compelling today than when was written due to the advancement of Artificial Intelligence and Genetic Engineering.

A plausible prophetic future for those willing to listen.

I thoroughly enjoyed reading nine of Westerman's books, some of them twice. This is literary contemporary history. Aside from a place, a period, and a prism through which to look, Frank combines award-winning literary skills with a journalistic journey. His stories are both big and small, personal and universal. Here he follows a fascinating 20th-century journey of the so-called ‘most pure’ horses of Europe. Through that story, you will find yourself cantering through the nature versus nurture debate that defined much of Europe’s recent history. On top of all that, I also recognise his journey through life, from his studies to ‘development’ work to foreign journalism to literary non-fiction writing on the big issues at the people & places interface. 

An absolute achievement of imagination, Torishima’s collection of novellas and novelettes is set in a future in which humans, machines, and alien life are as intertwined as the stories themselves. Attempting to sum up the various horrifying, chaotic and enigmatic worlds of this book is a fool’s errand; its breadth is staggering and can only be read to be understood. Even then, you will likely be left with more questions than answers. Sisyphean stretches itself to the breaking point and then challenges the reader to keep going, to open one’s mind to a torrid future populated by creatures who retain their humanity, but little else. Thankfully, Torishima offers his own illustrations to help you along.

I’m a geek for a good undercover story because of the constant underlying tension. Place that undercover story in an alternate world, and you’ve got my attention! Leviathan takes place in Scott Westerfeld's fabulous re-imagining of the events surrounding WWI. It’s a world where the secrets of DNA were discovered far earlier and put to use as natural “machinery.”

Our star is Deryn Sharp, one of my favorite middle-grade heroines. She’s a commoner disguised as a boy in the British Air Service. She's a brilliant airman, brave and fearless and clever… and living in constant fear someone will discover her secret. Even so, she faces conflict head-on and is quick on her feet.

She fights on the side of the Darwinists, using extraordinary genetically altered creatures, against the Clankers and their steampunk-style weaponry. They’re no match for Deryn, though, as she saves the day again and again with her mind… show more.