I’m a British science editor and author of a string of books on the scientific, medical, and social implications of advances in genetics research. I trained as a geneticist but found more personal satisfaction wielding a pen rather than a pipette. I’m especially drawn to science stories that have medical implications for the public and a strong narrative thread. Prior to writing Editing Humanity, I covered the race for the BRCA1 breast cancer gene (Breakthrough), the Human Genome Project (Cracking the Genome), and the rise of personal genomics (The $1,000 Genome). I’m currently writing a biography of sickle cell disease, arguably the most famous genetic mutation in human history.
A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).
The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.
BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize
“A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
This book starts and ends with the story of Dr. Jiankui He, the infamous Chinese researcher responsible for the first CRISPR experiment resulting in genetically modified children.
It chronicles Dr. He’s “meteoric rise to fame” followed by his “dramatic fall from grace.”
In telling this story Kirksey, a cultural anthropologist, entertains the reader with details about interesting characters he meets and places he visits in his quest to both situate this debacle in relation to earlier efforts at genetic engineering and cell therapy in the United States and to confirm some of the contested details about what did or did not happen in China in the years leading up to this “first”.
Along the way, Kirksey lays bare salient facts about conflicts of interests among scientists, the corporate world’s vaunted pursuit of profit, and the ways in which nationalistic aspirations seed unhealthy competition.
Longlisted for the Baillie Gifford Prize 2021 An anthropologist visits the frontiers of genetics, medicine, and technology to ask: whose values are guiding gene-editing experiments, and what are the implications for humanity? At a conference in Hong Kong in November 2018, Dr. Jiankui He announced that he had created the first genetically modified babies-twin girls named Lulu and Nana-sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for "illegal medical practice." As scientists elsewhere start to catch up with China's vast genetic research programme, gene editing is fuelling an innovation…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
Somewhat paradoxically, this treatise against genetic enhancement starts with the case of a deaf couple who want to have a deaf child.
This is a case I often discuss in exploring the difference between disease, disability, and diversity. Following on from this case description, Sandel asks, “Is it wrong to make a child deaf by design?” And what if the desired trait was not deafness but height, athletic prowess, health, or intelligence, and the aim was to gain a competitive advantage?
Would your answer be the same? In the pages that follow, Sandel builds a case against “reengineering our nature” grounded in an ethic of giftedness (i.e., a reverence for life as a gift).
He eschews the drive to mastery and insists that “[t]o appreciate children as gifts is to accept them as they come, not as objects of our design, or products of our will, or instruments of our…
"Sandel explores a paramount question of our era: how to extend the power and promise of biomedical science to overcome debility without compromising our humanity. His arguments are acute and penetrating, melding sound logic with compassion." -Jerome Groopman, author of How Doctors Think
Breakthroughs in genetics present us with a promise and a predicament. The promise is that we will soon be able to treat and prevent a host of debilitating diseases. The predicament is that our newfound genetic knowledge may enable us to manipulate our nature-to enhance our genetic traits and those of our children. Although most people find…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
This work of fiction highlights the potential dangers of genetic engineering.
It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.
In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.
Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer.
For fans of Julia Buckley and Tess Gerritsen, a debut featuring a killer in plain sight using a microscopic murder weapon, the cutting edge gene-editing technology: CRISPR.
Boston geneticist Dr. Saul Kramer is on the cutting edge of genetic disease research. Revered among clients at his IVF clinic, he harbors a dark secret. In addition to helping infertile couples conceive healthy babies, Dr. Kramer is obsessed, for his own dark reasons, with an alternate mission as well. In certain patients, he uses the gene editing technology CRISPR to tamper with embryos, not to improve the health of the embryos, but…
I’m a British science editor and author of a string of books on the scientific, medical, and social implications of advances in genetics research. I trained as a geneticist but found more personal satisfaction wielding a pen rather than a pipette. I’m especially drawn to science stories that have medical implications for the public and a strong narrative thread. Prior to writing Editing Humanity, I covered the race for the BRCA1 breast cancer gene (Breakthrough), the Human Genome Project (Cracking the Genome), and the rise of personal genomics (The $1,000 Genome). I’m currently writing a biography of sickle cell disease, arguably the most famous genetic mutation in human history.
British author, broadcaster and zoologist Matthew Cobb has written several books about the history of DNA research.
As Gods (the book’s original UK title is The Genetic Age) is a fast-paced analysis of “the thrilling and terrifying” 50-year history of genetic engineering and the rise of the biotechnology complex. But Cobb also asks tough questions regarding our propensity to meddle with nature, including the 2018 CRISPR babies scandal, reaching the unsettling conclusion that “dreams and nightmares must go hand in hand”.
The thrilling and terrifying history of genetic engineering
In 2018, scientists manipulated the DNA of human babies for the first time. As biologist and historian Matthew Cobb shows in As Gods, this achievement was one many scientists have feared from the start of the genetic age. Four times in the last fifty years, geneticists, frightened by their own technology, have called a temporary halt to their experiments. They ought to be frightened: Now we have powers that can target the extinction of pests, change our own genes, or create dangerous new versions of diseases in an attempt to prevent future…
Each book has its own story to tell, so there is not one particular book I love. Reading books that aren't my usual reads is something I enjoy doing. You may enjoy the following books, which I have listed. It made me think differently than I usually do, and as with most books I read, it will enhance your writing. Throughout my childhood, I always enjoyed reading to escape reality and get lost in a world of fantasy. As a result, I began writing science fiction that resembles me that is getting away.
We meet Phoenix, a woman grown in New York's Tower 7.
Even though she's only two years old, she has the mind and body of an adult, along with superhuman abilities. The death of her lover under dubious circumstances proves that Tower 7 is less of a home and more of a prison for Phoenix. She escapes to Ghana, where she learns brutal truths about colonialism and vows to fight back. Phoenix's fight for justice is electrifying.
A fiery spirit dances from the pages of the Great Book. She brings the aroma of scorched sand and ozone. She has a story to tell....
The Book of Phoenix is a unique work of magical futurism. A prequel to the highly acclaimed, World Fantasy Award-winning novel, Who Fears Death, it features the rise of another of Nnedi Okorafor's powerful, memorable, superhuman women.
Phoenix was grown and raised among other genetic experiments in New York's Tower 7. She is an "accelerated woman"-only two years old but with the body and mind of an adult, Phoenix's abilities far exceed those of…
I read widely and in many genres, so coming up with a thematic list was a difficult task. However, in working on my forthcoming novel Dead Ends, in which a quiet neighborhood descends into paranoia and insanity driven by fear, politics, and technology, I sought out novels that engaged with conspiratorial thinking and violence. I admire writers who don’t hold back and fully engage with their characters and material, particularly if it means going to dark, imaginative and strange places in their work. Please keep an eye out for Dead Ends, coming from Flame Tree Press in 2023.
An absolute achievement of imagination, Torishima’s collection of novellas and novelettes is set in a future in which humans, machines, and alien life are as intertwined as the stories themselves. Attempting to sum up the various horrifying, chaotic and enigmatic worlds of this book is a fool’s errand; its breadth is staggering and can only be read to be understood. Even then, you will likely be left with more questions than answers. Sisyphean stretches itself to the breaking point and then challenges the reader to keep going, to open one’s mind to a torrid future populated by creatures who retain their humanity, but little else. Thankfully, Torishima offers his own illustrations to help you along.
Even after the world and humanity itself have been rendered nearly unrecognizable by genetic engineering, a day in the office can feel...Sisyphean.
The company stands atop a tiny deck supported by huge iron columns a hundred meters high. The boss there is its president-a large creature of unstable, shifting form once called "human." The world of his dedicated worker contains only the deck and the sea of mud surrounding it, and and the worker's daily routine is anything but peaceful. A mosaic novel of extreme science and high weirdness, Sisyphean will change the way you see existence itself.
When I was a doctoral student in historical musicology, I went to Paris to study postwar government budgets for music, but it was really boring. So I started hanging out listening to Parisian songbirds instead. The more I learned about birdsong, the more I realized it raised some really big questions, like why biologists and musicians have completely different standards of evidence. Those questions led me to write my book, which is about what it means to sing if you’re not considered fully human, and most of my work today is about how thinking about animals can help us understand what we value in those who are different.
Butler is known for bringing a black, feminist, and queer perspective to science fiction, a genre of futuristic and outer-space storytelling that traditionally features white male protagonists.
But what really captivates me about this book, which is set in a post-apocalyptic future where human survivors are mated with their alien rescuers (really!), is the way it asks icky-yet-intensely-meaningful questions. What does it mean to “be human” in a future of genetic hybridity and gender fluidity? What does it mean to love a partner or children whose genetics and culture are radically different from your own? When is violence futile, and when is it the only way to be heard?
I’m pretty much obsessed with this book, and I promise that any reader who has thought deeply about what it means to be really different will love it too.
I’ve always been fascinated by the razor-thin line between innovation and disaster—where progress often conceals a darker potential. As a Gen-Xer who grew up questioning authority, speculative fiction became my outlet for exploring these precarious themes. Now, as an author, I channel that curiosity into stories that push the boundaries of ethical ambition, forcing us to confront the unsettling truths behind our technological dreams. This list reflects my deep love for sci-fi thrillers that don’t just entertain but challenge us to examine the hidden costs of our relentless pursuit of progress.
This book left me questioning what it truly means to be human. From the moment Logan Ramsay was infected with a mysterious virus, I was captivated by Crouch’s exploration of genetic enhancement. As Logan's abilities expanded—making him smarter, stronger, and more detached—I was both fascinated and horrified.
The tension between his new capabilities and the erosion of his emotional connections made the ethical dilemmas even more poignant. Crouch’s vision of a world on the brink of extinction, with genetic upgrades as both a salvation and a curse, felt disturbingly real. This isn’t just a techno-thriller; it’s a profound examination of what we might sacrifice in the relentless pursuit of progress.
I have always been fascinated by the workings of the human mind.What instincts and influences make us who we are? This Alien Shore grew out of research I was doing into atypical neurological conditions.It depicts a society that has abandoned the concept of “neurotypical”, embracing every variant of human perspective as valid and valuable. One of my main characters, Kio Masada, is autistic, and that gives him a unique perspective on computer security that others cannot provide. What might such a man accomplish, in a world where his condition is embraced and celebrated? Good science fiction challenges our definition of “Other,” and asks what it really means to be human, all in the context of an exciting story.
A planet in its equivalent of the stone age is passing through a galactic debris field. An alien stargazer realizes that sooner or later some object will strike the planet and destroy it. The only hope of survival his species has is to leave the planet before that happens. But the concept is a mere abstraction to his people, the equivalent of a Neanderthal saying “we need to travel to the moon,” and the task is further complicated by the fact that their technology is biological in nature, focused on the manipulation of living tissue. It is hard to imagine how such technology could ever produce a spaceship.
The novel--structured as a series of novellas-- follows the development of a fascinating alien species from its primitive roots to an age of high technology, each chapter focusing on a different time period. Always the stargazer’s warning is proclaimed by a few…
Traces the development over milennia of a civilization of an unusual alien species, whose sense of humor, resourceful adaptibility, and metalworking skills are the strengths and the hope of their society
