100 books like The Case against Perfection

A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).

The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.

This book starts and ends with the story of Dr. Jiankui He, the infamous Chinese researcher responsible for the first CRISPR experiment resulting in genetically modified children.

It chronicles Dr. He’s “meteoric rise to fame” followed by his “dramatic fall from grace.”

In telling this story Kirksey, a cultural anthropologist, entertains the reader with details about interesting characters he meets and places he visits in his quest to both situate this debacle in relation to earlier efforts at genetic engineering and cell therapy in the United States and to confirm some of the contested details about what did or did not happen in China in the years leading up to this “first”.

Along the way, Kirksey lays bare salient facts about conflicts of interests among scientists, the corporate world’s vaunted pursuit of profit, and the ways in which nationalistic aspirations seed unhealthy competition.

This work of fiction highlights the potential dangers of genetic engineering.

It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.

In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.

Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer. 

Many assert that “science is outpacing ethics.”

In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”

In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.

He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.

British author, broadcaster and zoologist Matthew Cobb has written several books about the history of DNA research.

As Gods (the book’s original UK title is The Genetic Age) is a fast-paced analysis of “the thrilling and terrifying” 50-year history of genetic engineering and the rise of the biotechnology complex. But Cobb also asks tough questions regarding our propensity to meddle with nature, including the 2018 CRISPR babies scandal, reaching the unsettling conclusion that “dreams and nightmares must go hand in hand”.

Butler is known for bringing a black, feminist, and queer perspective to science fiction, a genre of futuristic and outer-space storytelling that traditionally features white male protagonists.

But what really captivates me about this book, which is set in a post-apocalyptic future where human survivors are mated with their alien rescuers (really!), is the way it asks icky-yet-intensely-meaningful questions. What does it mean to “be human” in a future of genetic hybridity and gender fluidity? What does it mean to love a partner or children whose genetics and culture are radically different from your own? When is violence futile, and when is it the only way to be heard?

I’m pretty much obsessed with this book, and I promise that any reader who has thought deeply about what it means to be really different will love it too.

When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.

The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.

Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative. 

This book has only just come out, and I couldn’t resist gobbling it up when I saw the similarities between it and my own The Unadjusteds. Green Rising adds the focus of environmental concerns, and what might happen in the future when people develop unique abilities that can harness nature and plants. This book combines my passions for the environment and mental health, with James’ fabulous style and voice. Based in a near future, some of the circumstances cut close to the bone and make me wonder what our future may hold.

I really enjoy hard science fiction—science fiction that uses real science—and Shivering World is an excellent example of the subgenre.

The story revolves around terraforming and genetic research, but there is a lot more going on here. Politics, faith, power struggles, survival situations, and the main character’s search for a cure to her genetic condition create a delightful mix that rivals what’s found in sci-fi classics, like Dune and Foundation.

The author’s background in microbiology, music, and education brings a new level of believability to the story. Kathy Tyers is best known for Star Wars novels and her Firebird series, but I think her standalone books are fantastic.

This one is totally different than the others on my list, but when I was diving into these related genres and finding myself more and more inspired by them, it was always a surprise and a treat to find a book that just completely defied all genre expectations. The book blends Sci-Fi with Fantasy, something I’ve always enjoyed if done well, and something that made me think maybe I could try my hand at this. I was never that great in science or math, even though I tried, but the idea that we could mix Sci-Fi with Fantasy, now that was intriguing. And throw in a little unexpected romance and I think you have a really well-rounded adventure. Humans are the root cause of the ending of the human race, so obviously humans have to undo what they’ve done, but your average person is just trying to survive the fallout.