Here are 100 books that The Case against Perfection fans have personally recommended if you like
The Case against Perfection.
Shepherd is a community of 12,000+ authors and super readers sharing their favorite books with the world.
I’m a British science editor and author of a string of books on the scientific, medical, and social implications of advances in genetics research. I trained as a geneticist but found more personal satisfaction wielding a pen rather than a pipette. I’m especially drawn to science stories that have medical implications for the public and a strong narrative thread. Prior to writing Editing Humanity, I covered the race for the BRCA1 breast cancer gene (Breakthrough), the Human Genome Project (Cracking the Genome), and the rise of personal genomics (The $1,000 Genome). I’m currently writing a biography of sickle cell disease, arguably the most famous genetic mutation in human history.
A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).
The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.
BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize
“A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
This book starts and ends with the story of Dr. Jiankui He, the infamous Chinese researcher responsible for the first CRISPR experiment resulting in genetically modified children.
It chronicles Dr. He’s “meteoric rise to fame” followed by his “dramatic fall from grace.”
In telling this story Kirksey, a cultural anthropologist, entertains the reader with details about interesting characters he meets and places he visits in his quest to both situate this debacle in relation to earlier efforts at genetic engineering and cell therapy in the United States and to confirm some of the contested details about what did or did not happen in China in the years leading up to this “first”.
Along the way, Kirksey lays bare salient facts about conflicts of interests among scientists, the corporate world’s vaunted pursuit of profit, and the ways in which nationalistic aspirations seed unhealthy competition.
Longlisted for the Baillie Gifford Prize 2021 An anthropologist visits the frontiers of genetics, medicine, and technology to ask: whose values are guiding gene-editing experiments, and what are the implications for humanity? At a conference in Hong Kong in November 2018, Dr. Jiankui He announced that he had created the first genetically modified babies-twin girls named Lulu and Nana-sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for "illegal medical practice." As scientists elsewhere start to catch up with China's vast genetic research programme, gene editing is fuelling an innovation…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
This work of fiction highlights the potential dangers of genetic engineering.
It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.
In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.
Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer.
For fans of Julia Buckley and Tess Gerritsen, a debut featuring a killer in plain sight using a microscopic murder weapon, the cutting edge gene-editing technology: CRISPR.
Boston geneticist Dr. Saul Kramer is on the cutting edge of genetic disease research. Revered among clients at his IVF clinic, he harbors a dark secret. In addition to helping infertile couples conceive healthy babies, Dr. Kramer is obsessed, for his own dark reasons, with an alternate mission as well. In certain patients, he uses the gene editing technology CRISPR to tamper with embryos, not to improve the health of the embryos, but…
I'm a philosopher with a specialization in bioethics. My work is at the intersection of policy and practice. It is grounded in a deep commitment to public education, engagement, and empowerment, as well as a strong desire to “make the powerful care.” I maintain that “the human genome belongs to us all. It’s something we have in common, and so we all have the right to have a say.” I believe the pivotal question that we all need to ask is “What kind of world do we want to live in?” Once we have an answer to this question, we can meaningfully address the more pointed question, “Will CRISPR technology help us build that world?”
In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”
In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.
He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.
This was the first philosophical book on the ethics of genetic choices, and (in its second half) the first book on what is now called “neuroethics”: questions about mood-changing drugs, about inhabiting virtual realities, and about the use of brain-scanning techniques to access the contents of people’s minds. "This book is about some questions to do with the future of mankind. The questions have been selected on two grounds. They arise out of scientific developments whose beginnings we can already see, such as genetic engineering and behaviour control. And they involve fundamental values: these technologies may change the central framework…
I’m a British science editor and author of a string of books on the scientific, medical, and social implications of advances in genetics research. I trained as a geneticist but found more personal satisfaction wielding a pen rather than a pipette. I’m especially drawn to science stories that have medical implications for the public and a strong narrative thread. Prior to writing Editing Humanity, I covered the race for the BRCA1 breast cancer gene (Breakthrough), the Human Genome Project (Cracking the Genome), and the rise of personal genomics (The $1,000 Genome). I’m currently writing a biography of sickle cell disease, arguably the most famous genetic mutation in human history.
British author, broadcaster and zoologist Matthew Cobb has written several books about the history of DNA research.
As Gods (the book’s original UK title is The Genetic Age) is a fast-paced analysis of “the thrilling and terrifying” 50-year history of genetic engineering and the rise of the biotechnology complex. But Cobb also asks tough questions regarding our propensity to meddle with nature, including the 2018 CRISPR babies scandal, reaching the unsettling conclusion that “dreams and nightmares must go hand in hand”.
The thrilling and terrifying history of genetic engineering
In 2018, scientists manipulated the DNA of human babies for the first time. As biologist and historian Matthew Cobb shows in As Gods, this achievement was one many scientists have feared from the start of the genetic age. Four times in the last fifty years, geneticists, frightened by their own technology, have called a temporary halt to their experiments. They ought to be frightened: Now we have powers that can target the extinction of pests, change our own genes, or create dangerous new versions of diseases in an attempt to prevent future…
When I was a doctoral student in historical musicology, I went to Paris to study postwar government budgets for music, but it was really boring. So I started hanging out listening to Parisian songbirds instead. The more I learned about birdsong, the more I realized it raised some really big questions, like why biologists and musicians have completely different standards of evidence. Those questions led me to write my book, which is about what it means to sing if you’re not considered fully human, and most of my work today is about how thinking about animals can help us understand what we value in those who are different.
Butler is known for bringing a black, feminist, and queer perspective to science fiction, a genre of futuristic and outer-space storytelling that traditionally features white male protagonists.
But what really captivates me about this book, which is set in a post-apocalyptic future where human survivors are mated with their alien rescuers (really!), is the way it asks icky-yet-intensely-meaningful questions. What does it mean to “be human” in a future of genetic hybridity and gender fluidity? What does it mean to love a partner or children whose genetics and culture are radically different from your own? When is violence futile, and when is it the only way to be heard?
I’m pretty much obsessed with this book, and I promise that any reader who has thought deeply about what it means to be really different will love it too.
Ever since middle school, when our teacher promised that we would have
flying cars in our lifetimes, I’ve had a keen interest in scientific
and technological breakthroughs. And now, with the advancements in
Artificial Intelligence and genetic engineering, my interest has only
grown. I love technology, but my concern is that with the acceleration
of AI, science is outpacing common sense. Are we creating our
replacements? I hope you read my new novel: Crystal and the
Underlings: the future of humanity, and discover what could happen
when AI takes over!
When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.
The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.
Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative.
The Number One international bestselling author of Jurassic Park, Congo and Sphere blends fact and fiction to create a near-future where genetic engineering opens up a whole new world of terrifying, page-turning possibilities...
Is a loved one missing body parts? Are blondes becoming extinct? Has a human already cross-bred with a monkey?
We live in a GENETIC WORLD. Fast, frightening - and potentially VERY lucrative. There are designer pets; a genetic cure for drug addiction; a booming market in eggs and sperm. But is there also a talking ape in Borneo? Has a 'master' gene for controlling others been found?…
I've always been fascinated by genetics. Ever since Dolly the Sheep was cloned in the 1990s, I wondered if it was possible for it to have a soul, was it a carbon copy, did it know it had a twin? Move on to when I studied biology and then psychology. My brother became a genetic scientist, and we have both always been fascinated by the possibilities. Although the human genome project has been declared complete, there is still much we don’t know about genetics, let alone what we may harness from the animals around us. Although I'm excited to find out, I'm also fearful of how these modifications may be used.
This book has only just come out, and I couldn’t resist gobbling it up when I saw the similarities between it and my own The Unadjusteds. Green Rising adds the focus of environmental concerns, and what might happen in the future when people develop unique abilities that can harness nature and plants. This book combines my passions for the environment and mental health, with James’ fabulous style and voice. Based in a near future, some of the circumstances cut close to the bone and make me wonder what our future may hold.
Set in a near-future world on the brink of ecological catastrophe, Lauren James's novel is a gripping, witty and romantic call to arms.
Gabrielle is a climate-change activist who shoots to fame when she becomes the first teenager to display a supernatural ability to grow plants from her skin. Hester is the millionaire daughter of an oil tycoon and the face of the family business. Theo comes from a long line of fishermen, but his parents are struggling to make ends meet.
On the face of it, the three have very little in common. Yet when Hester and Theo join…
A computer programmer turned author; I’ve been a fan of science fiction for as long as I remember. Star Wars, Dune, Alien, you name it. I’ve also been a follower of Christ since childhood and so enjoy stories where authors have a faith component to their work. It’s hard to imagine a future where belief systems won’t be in play—for good and evil. So, why not explore that element? Even if it means taking the Amish into space to encounter vampires? (As I did in one of my stories.) Hopefully, we discover something about ourselves and the world we live in along the way.
I really enjoy hard science fiction—science fiction that uses real science—and Shivering World is an excellent example of the subgenre.
The story revolves around terraforming and genetic research, but there is a lot more going on here. Politics, faith, power struggles, survival situations, and the main character’s search for a cure to her genetic condition create a delightful mix that rivals what’s found in sci-fi classics, like Dune and Foundation.
The author’s background in microbiology, music, and education brings a new level of believability to the story. Kathy Tyers is best known for Star Wars novels and her Firebird series, but I think her standalone books are fantastic.
A planet on the edge of life. A woman on the edge of hope.
Microbiologist Graysha Brady-Phillips accepts a hazardous position assisting in terraforming the planet Goddard, partly to get out of debt and partly in desperate hope. There's a chance that the colonists are conducting illegal genetic research, which could provide a cure for the genetic disorder slowly killing her.
But genetic engineering is banned by the powerful Eugenics Board, and Graysha is the daughter of the board’s high commissioner. When the colonists discover her connection, she is ostracized—the possible penalties for conducting their…
Since my first trip to Oz, Dad’s voice traveling me to sleep, I’ve been in love with fantastic worlds, from the microscopic to the intergalactic. I’m drawn to the observations of poets, astronomers, and metaphysicians, but there’s a special place in my heart for children’s authors. Someone once told me middle grade is the “sweet spot.” Readers start making independent choices, exploring stories that resonate with them. I’ve been teaching world-building to students and writers of all ages since 1998, and there is something magical about those 8-12 year-olds with their wild imaginations and eagerness to explore. I wrote my fantasy series for 10-year-old me, lost in such worlds.
I’m a geek for a good undercover story because of the constant underlying tension. Place that undercover story in an alternate world, and you’ve got my attention! Leviathan takes place in Scott Westerfeld's fabulous re-imagining of the events surrounding WWI. It’s a world where the secrets of DNA were discovered far earlier and put to use as natural “machinery.”
Our star is Deryn Sharp, one of my favorite middle-grade heroines. She’s a commoner disguised as a boy in the British Air Service. She's a brilliant airman, brave and fearless and clever… and living in constant fear someone will discover her secret. Even so, she faces conflict head-on and is quick on her feet.
She fights on the side of the Darwinists, using extraordinary genetically altered creatures, against the Clankers and their steampunk-style weaponry. They’re no match for Deryn, though, as she saves the day again and again with her mind…
Two opposing forces are on the brink of war. The Clankers - who put their faith in machinery - and the Darwinists - who have begun evolving living creatures into tools. Prince Aleksandar, the would-be heir to the Austro-Hungarian throne, comes from a family of Clankers, and travels the country in a walker, a heavily-fortified tank on legs. Meanwhile Deryn Sharp, a girl disguised as a boy, works for the British Empire, crewing the ultimate flying machine: an airship made of living animals. Now, as Alek flees from his own people, and Deryn crash-lands in enemy territory, their lives are…
