100 books like The Gene

In this book, Rosling repeatedly and humbly shows how so many of the facts I thought I knew about the world—such as where energy comes from, how incomes compare across countries, or how many people are being affected by disasters—were just plain wrong.

I first saw Hans Rosling explaining the trajectories and development of countries using animated charts in a hugely popular TED talk. Through persuasive charts and explanations, he showed me how things can be bad and still be getting better and how the world has already improved in so many ways. I read it and was educated.

I love any book that gives me insight into the mind, and this book taught me so much about the tricks of how our minds tackle big and everyday decisions; I recommend it to people on the street.

Kahneman was the first and probably only psychologist to win a Nobel Prize in economics, and it was for this book.

Greek mythology that reads like a storybook.

I never thought I would enjoy reading Greek mythology. But how Fry wrote it is really amazing. Now, when I go to a museum and see an ancient painting depicting Greek Mythology, I am often able to explain what is visualised in the artwork.

In the book, Zeus and the other Gods get a true character and the fights they have are depicted in a way that you still want to read it till the end, even if you know what the end will look like. 

I love this book because it turns the most impactful science discovery of the 21st century–CRISPR gene editing–into a page-turner. Isaacson combines a biography of Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier, with lucid accounts of the science and sequence of research breakthroughs that underlie CRISPR editing, as well as the intrigues and jockeying among powerful scientists and personalities vying for prizes and patents on the technology.

I came through this book to appreciate the enormous potential of CRISPR gene editing for good (curing hereditary diseases) and not-so-good (designer babies or, in the words of Vladimir Putin, “a soldier, an individual who can fight without fear or compassion, mercy or pain”). CRISPR promises to make human selection as important as natural selection in the evolution of many species, including humans.

Now for some facts, although they will appear stranger than the fiction above. Born with a club foot and unable to join the army during World War II, Sydney Gottlieb became a leading covert warrior. For years, he oversaw some of the CIA’s most controversial programs. He developed poisons to kill foreign leaders and officials, and he worked in MKULTRA, the Agency’s program for mind control, which included the use of LSD, drugs, isolation, and other invasive experiments and forms of torture on witting and unwitting subjects.

The book is a detailed, if harrowing, history. It is even more impressive as most of the documents on these programs were destroyed by Gottlieb himself in 1973, under orders from the CIA Director at the time, Richard Helms. 

It is hard to believe that Matt Ridley’s grand tour of the human genome was published back in 1999. Yet even today, more than two decades later, Ridley’s engaging, chromosome by chromosome investigation of our genetic make-up remains a marvel that has never been equaled. From the genes that enable the most basic chemical processes in our cells to those that determine our height and eye color, the mysterious “junk DNA” that lives between our genes, and speculation about the ways that genes affect personality, behavior, and society, Ridley brings science to life in this engaging and timeless book.

James Watson was a clever, pushy, and critical young American molecular biologist exposed to the scientific culture of Britain in the early 1950s.

The book is full of acerbic comments about “stuffy” Cambridge dons and the rules of etiquette that young Jim struggled with, all the while scheming to maintain the various fellowships that allowed him to remain in the UK and pursue his ambition: to understand the chemical nature of the genetic material, DNA.

The book provides a lively account of his collaboration with an older Brit, the brilliant Francis Crick, who was also trying to unscramble DNA. Much of the technical stuff will be incomprehensible to most, but the method the two followed is clear. The partnership was hugely fruitful and the book is a lively account of how science actually works.

Watson and Crick tried everything while coping with competitors and their criticisms as well as their… show more.

This might not look like a big data book but, for me, the race to read the human genome marks the birth of big data in biology, in the form of a tsunami of DNA sequencing data. I edited Craig Venter’s A Life Decoded, the first genetic autobiography, which explored the implications of becoming the first person to gaze upon all six billion ‘letters’ of their own genetic code. While working on Craig’s extraordinary story I came across The Genome War and thought James Shreeve did a brilliant job in describing the drama, rivalry, and personalities in the race to sequence the very first human genomes between government-backed scientists and Celera, Craig’s company.

We live in the most medically protected time in human history. Before about two hundred years ago, we were utterly helpless against infectious diseases – we could neither see nor conceive of what caused them. This book, written in the 1920s, tells in vivid prose, the story of the discovery of microbes, beginning with the Dutch businessman who ground the first lenses enabling the human eye to see the “animalcules” that Louis Pasteur and others eventually matched with their deadly effects, enabling humanity to begin to fight back.

Most of us can’t even pronounce the names of the childhood diseases vaccines have almost eradicated, nor can we imagine the parental grief, and childhood suffering, that those diseases routinely inflicted on families until well into the 20th Century. This comprehensive history reminds us that the development of vaccines was always a see-saw between life-saving advances, and terrible mistakes and failures.