I love to hear stories about how people solve problems, and I have been curious about how science works since I was 12 years old. A decade later, when I was 22 years old, some of my friends joked that I "spoke DNA," and it’s true that I have been obsessed with trying to understand the physical structures of DNA for more than four decades now. I live my life vicariously through my students and help them to learn to tinker, troubleshoot, and recover from their failures.
I wrote...
Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists
The major difficulty many microbiologists face is simply that of too much information. As a result of sequencing technologies becoming so economical, there is a very real and pressing need for high-throughput computational methods to compare thousands of bacterial genomes.
The book starts with “Cells obey the laws of physics and chemistry” and introduces the biochemistry/molecular biology necessary for explaining biological information. This is followed by chapters introducing tools and a methodological framework for comparing genome sequences, then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Computational/bioinformatics methods for comparison of microbial genomes can be done at the level of DNA, RNA, and proteins.
I love François Jacob’s book. One of my favorite quotes from this is, "Evolution is a tinkerer."
I think that this is a great insight from one of the founders in the field, who shared the Nobel prize in 1965, for showing how genetic information flows from DNA to RNA to protein and that the control or regulation of this could come from proteins binding to regions of DNA upstream from genes.
"The most remarkable history of biology that has ever been written."-Michel Foucault
Nobel Prize-winning scientist Francois Jacob's The Logic of Life is a landmark book in the history of biology and science. Focusing on heredity, which Jacob considers the fundamental feature of living things, he shows how, since the sixteenth century, the scientific understanding of inherited traits has moved not in a linear, progressive way, from error to truth, but instead through a series of frameworks. He reveals how these successive interpretive approaches-focusing on visible structures, internal structures (especially cells), evolution, genes, and DNA and other molecules-each have their own…
I really enjoyed this book and have found it a wonderful reference, mapping the history of the quest for trying to figure out how biological information is stored (in the form of DNA in chromosomes), and how biological information flows from DNA to RNA to proteins.
The book is long and exhaustive, but it’s one of my favorites!
I love the way that this book puts solving the genetic code in the
context of the development of the "information age" in the 1950s.
This
book explains the origins of the popular (but wrong) idea that DNA is the "book of life" and some sort of advanced information
system. I call this a ‘one-dimensional’ view of life (as opposed to a four-dimensional view, which takes into account not just sequence but
secondary and tertiary structures and how they change with time).
I use
this book in my introductory bioinformatics
lectures to help get across the "new" concept that, contrary to
popular cultural beliefs, DNA is not a language, nor is it a
'sophisticated computer code’. Biology is messy and complicated and
very much contextual.
This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States.
I love to hear stories from the people doing the work, making the discoveries, detailing how science works - sometimes false leads, sometimes by luck, and most importantly, by testing ideas and being careful to make sure that things are not proven wrong. Nothing is ever 100% certain in science, but things that are falsifiable and have stood the test of time are more believable.
I remember being surprised to slowly realize that solving the genetic code was not done by computer scientists but by the experimentalists (biochemists) who used trial and error to see what proteins are made from various combinations of different DNA sequences (for example, a DNA strand that contains only A’s makes a protein with only lysine, so the triple ‘AAA’ makes lysine).
A collection of reprinted articles from the review journal Trends in Biochemical Sciences (TiBS) focusing on the central dogma of molecular biology--DNA makes RNA makes protein. The biographical and autobiographical articles graphically describe the great discoveries in the field from an insider's perspective.
I love to discuss this book with my students; this is a more recent (relative to the others) retelling of the story, with more details fleshed out through decades of scholarship in the area.
The author tells stories about his family and relates this to the discovery of the physical basis of heredity. This book was the inspiration for a Ken Burns series on PBS.
Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday
THE NEW YORK TIMES NUMBER ONE BESTSELLER BBC RADIO 4 BOOK OF THE WEEK
`Dramatic and precise... [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time... He is a natural storyteller... A page-turner... Read this book and steel yourself for what comes next' Bryan Appleyard, Sunday Times
The Gene is the story of one of the most powerful and dangerous ideas in our…
What happens when a novelist with a “razor-sharp wit” (Newsday), a “singular sensibility” (Huff Post), and a lifetime of fear about getting sick finds a lump where no lump should be? Months of medical mishaps, coded language, and Doctors who don't get it.
With wisdom, self-effacing wit, and the story-telling artistry of an acclaimed novelist, Elizabeth Benedict recollects her cancer diagnosis after discovering multiplying lumps in her armpit. In compact, explosive chapters, interspersed with moments of self-mocking levity, she chronicles her illness from muddled diagnosis to “natural remedies,” to debilitating treatments, as she gathers sustenance from family, an assortment of urbane friends, and a fearless “cancer guru.”
Rewriting Illness is suffused with suspense, secrets, and the unexpected solace of silence.
By turns somber and funny but above all provocative, Elizabeth Benedict's Rewriting Illness: A View of My Own is a most unconventional memoir. With wisdom, self-effacing wit, and the story-telling skills of a seasoned novelist, she brings to life her cancer diagnosis and committed hypochondria. As she discovers multiplying lumps in her armpit, she describes her initial terror, interspersed with moments of self-mocking levity as she indulges in "natural remedies," among them chanting Tibetan mantras, drinking shots of wheat grass, and finding medicinal properties in chocolate babka. She tracks the progression of her illness from muddled diagnosis to debilitating treatment…
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