41 books like The Genome War

I love this book because it turns the most impactful science discovery of the 21st century–CRISPR gene editing–into a page-turner. Isaacson combines a biography of Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier, with lucid accounts of the science and sequence of research breakthroughs that underlie CRISPR editing, as well as the intrigues and jockeying among powerful scientists and personalities vying for prizes and patents on the technology.

I came through this book to appreciate the enormous potential of CRISPR gene editing for good (curing hereditary diseases) and not-so-good (designer babies or, in the words of Vladimir Putin, “a soldier, an individual who can fight without fear or compassion, mercy or pain”). CRISPR promises to make human selection as important as natural selection in the evolution of many species, including humans.

It is hard to believe that Matt Ridley’s grand tour of the human genome was published back in 1999. Yet even today, more than two decades later, Ridley’s engaging, chromosome by chromosome investigation of our genetic make-up remains a marvel that has never been equaled. From the genes that enable the most basic chemical processes in our cells to those that determine our height and eye color, the mysterious “junk DNA” that lives between our genes, and speculation about the ways that genes affect personality, behavior, and society, Ridley brings science to life in this engaging and timeless book.

Over a single year, Giorgia Lupi, an Italian living in New York, and Stefanie Posavec, an American in London, exchanged hand-drawn postcards to chart the granular details of their lives using clusters, plots, and graphs. We featured the outpourings of these talented “information designers” in a 2016 Science Museum exhibition on big data and these striking images, in turn, paved the way for their book, Dear Data, which provides a remarkable portrait of these artists. An intimate and human take on big data that invites us all to ponder how to represent our own lives.   

James Watson was a clever, pushy, and critical young American molecular biologist exposed to the scientific culture of Britain in the early 1950s.

The book is full of acerbic comments about “stuffy” Cambridge dons and the rules of etiquette that young Jim struggled with, all the while scheming to maintain the various fellowships that allowed him to remain in the UK and pursue his ambition: to understand the chemical nature of the genetic material, DNA.

The book provides a lively account of his collaboration with an older Brit, the brilliant Francis Crick, who was also trying to unscramble DNA. Much of the technical stuff will be incomprehensible to most, but the method the two followed is clear. The partnership was hugely fruitful and the book is a lively account of how science actually works.

Watson and Crick tried everything while coping with competitors and their criticisms as well as their… show more.

Once upon a time, we were unaware of DNA. We could tell that taller parents have taller kids, we could select tomato plants for sweeter fruit, and we could even construct plausible relationships between long-extinct animals and their descendants. Still, the nature of the stuff from which these links are made and how it works or fails to work remained a mystery.

Solving this mystery is one of humanity’s most remarkable achievements, and Mukherjee tells the tale with style and humor, weaving in recollections of his family’s encounters with mental illness. Despite my familiarity with the end result, the modern picture of genes, I found much of the history surprising and surprisingly colorful, full of dead ends and creative leaps. The last third of the book, on complex traits like intelligence and illnesses like schizophrenia, isn’t quite as good as the rest, but that takes us to our second… show more.

A primary reason to love math is because of its usefulness. This book shows two sides of math’s applicability, since it is so ubiquitously used in various algorithms.

On the one hand, such usage can be good, because statistical inferences can make our life easier and enrich it. On the other, when these are not properly designed or monitored, it can lead to catastrophic consequences. Mathematics is a powerful force, as powerful as wind or fire, and needs to be harnessed just as carefully.

Cathy O’Neil’s message in this book spoke deeply to me, reminding me that I need to be always vigilant about the subject I love not being deployed carelessly.  

Big data can be beautiful and visualisations make for a wonderful coffee-table book. In Information is Beautiful, David McCandless turns dry-as-dust data into pop art to show the kind of world we live in, linking politics to life expectancy, women’s education to GDP growth, and more. Through colourful graphics, we get vivid and novel perspectives on current obsessions, from maps of cliches to the most fashionable colours. A testament to how the power of big data comes from being able to distill information to reveal hidden patterns and discern trends. 

‘They trust me….dumb f*cks.’ This telling exchange from the Harvard days of Facebook co-founder and CEO, Mark Zuckerberg appears in An Ugly Truth, which shines a harsh light on the tech behemoth that, ultimately, is built on the data of billions of people. As Meta, Zuckerberg’s new business incarnation, wafts into the virtual worlds of the metaverse, the story of Facebook is far from over, which makes this engaging book a tad unsatisfying. Nonetheless, it is a vivid example of how with Big Data comes Big Responsibility.

This is one of those books that you have to read either alone or among tolerant friends, because every few pages you’ll be moved to read some bit of it aloud to everyone around you. Alondra Nelson is a brilliant sociologist of science and technology, and this book tells the story of how genetic science and racial politics intersect, sometimes in surprising ways. I love how this book intertwines cultural and political history with clear-eyed analysis of genomics, genealogy, and the life sciences—it’s a great example of how to write about the human stakes of scientific research and innovation.

The new science of DNA reveals a lot about how we think about identity.

Humans are a migratory species and our stories are complicated. Ancient DNA don't always match people's stories about their ancestors. Rather than being in a place for thousands of years, sometimes we replaced those who were there before or only the males of the group.

Sometimes we completely replaced the group that was there before but the original group's culture persisted or even replaced the invading culture. The book complicates our understanding of indigeneity and belonging.