89 books like The Double Helix

Richard Feynman was unique. A brilliant theoretical physicist, humorous, eccentric, and independent.

Feynman’s genius gave him a certain freedom, which he exploited to the full. The book is autobiographical and shows his often irresponsible behavior but also a relentless curiosity, and willingness to try anything, the essence of a successful scientist.

One cannot hope to imitate Feynman (and perhaps we should not: he was often mischievous, even mildly malicious); but any scientist should envy the way he approached problems in engineering as well as science—and the book is fun!

I have seldom read a book with as much zeal as The Code Breaker, written by the famous biographer and historian, Walter Isaacson, whom I’d met on the CRISPR conference circuit.

Isaacson focuses on Doudna’s life and science, but also introduces the reader to a large cast of characters, including Doudna’s former colleague and fellow Nobelist, Emmanuelle Charpentier. He even has a crack at running a CRISPR experiment himself.

The success of this book has likely done more than anything to educate the public on the transformative promise of CRISPR.

It is hard to believe that Matt Ridley’s grand tour of the human genome was published back in 1999. Yet even today, more than two decades later, Ridley’s engaging, chromosome by chromosome investigation of our genetic make-up remains a marvel that has never been equaled. From the genes that enable the most basic chemical processes in our cells to those that determine our height and eye color, the mysterious “junk DNA” that lives between our genes, and speculation about the ways that genes affect personality, behavior, and society, Ridley brings science to life in this engaging and timeless book.

This might not look like a big data book but, for me, the race to read the human genome marks the birth of big data in biology, in the form of a tsunami of DNA sequencing data. I edited Craig Venter’s A Life Decoded, the first genetic autobiography, which explored the implications of becoming the first person to gaze upon all six billion ‘letters’ of their own genetic code. While working on Craig’s extraordinary story I came across The Genome War and thought James Shreeve did a brilliant job in describing the drama, rivalry, and personalities in the race to sequence the very first human genomes between government-backed scientists and Celera, Craig’s company.

I love to discuss this book with my students; this is a more recent (relative to the others) retelling of the story, with more details fleshed out through decades of scholarship in the area.

The author tells stories about his family and relates this to the discovery of the physical basis of heredity. This book was the inspiration for a Ken Burns series on PBS.

Ritchie was part of a team that attempted to replicate a famous study led by a prominent psychologist, Daryl Bem, claiming that people did better on a word memorization test if they studied the words after taking the test.

Ritchie and his co-authors attempted to replicate this study and found no evidence supporting Bem’s claim. This is but one example of a scientific crisis in that attempts to replicate influential studies published in top peer-reviewed journals fail nearly half the time. Ritchie explains and illustrates the reasons for the current replication crisis in science.

Experimental Medicine is a classic, a clear and simple account of physiological research, well-illustrated with comprehensible examples (no molecular biology needed).

It is well worth reading if only because so many of the principles that French physician Claude Bernard pioneered have been largely forgotten. Most important is his demand for certainty: “Science permits no exceptions,” an injunction now more often forgotten than obeyed. Bernard would have been appalled by, for example, a famous choice experiment in which 60% of a large group of subjects choose a less-profitable option.

The experimenters concluded that individual humans (not just groups) show risk aversion, ignoring the 40% who did not. In a similar situation, Bernard would always seek the conditions that yield a 100% result. He gives an example where he was able to resolve uncertainty concerning the sensitivity of spinal roots.

We’re still waiting for any serious effort to achieve a Bernardian certainty… show more.

Any list of books about science must have something about Darwin. The book to read is The Origin. But that’s obvious. I don’t need to go into it. So here is a Darwin book that is less obvious.

Most scientists will never have heard of it; it’s literary history, not science. I learned of it by accident, in a talk given by an economic historian. This is a fascinating book by a literary historian from which I learned much about Darwin. Gillian Beer recognizes that Darwin was a great writer. She traces similarities between his rhetorical style and the strategies of some other iconic Victorian writers, such as George Eliot (Middlemarch) and Samuel Butler (The way of all flesh).

She also discusses scientific writers of the era such as George Lewis and Herbert Spencer. There are many revealing long quotations. I learned much from the… show more.

Marie Benedict has written several novels now about overshadowed women in history, and this one might be my favorite.

Rosalind Franklin was the talented chemist whose experiments in X-ray crystallographic imaging were crucial to uncovering the double helix structure of DNA – a discovery, of course, long attributed exclusively to her former colleagues Francis Crick, James Watson, and Maurice Wilkins.

Benedict does a fabulous job of portraying the difficulties Rosalind faces as a female scientist in this era, constantly disrespected by many of her male colleagues and denied formal recognition by the scientific establishment.

I was fascinated (if at times infuriated on Rosalind’s behalf!) by this book, and also enjoyed the insight into Rosalind’s life as a Jewish woman in Europe in the shadow of WWII. 

All of Powers’ books are brilliant, for all kinds of reasons. I remember this book when it first came out decades ago. First of all, it’s just great entertainment, a great story with rich characters. Then, at the same time, Powers captures the beauty of science and discovery as he immerses the reader in the time after the discovery of the double-helical structure of DNA when there was a mad rush to figure out how DNA could encode proteins. Powers captures it all and gets the science right and brings in similarities between the DNA code and music and captures what it’s like working in a lab. How is this possible?