10 books like The Social Life of DNA

Eventually, I had to have a mainstream book, right?

This book is a masterpiece thanks to Ms. Skloot’s extraordinary writing and her clear empathy for her subject, the Lacks family. This is so much more than the revelation of a medical marvel—the Lacks cells that have led to so many medical discoveries.

This is a story about racial equity in the healthcare system, about personal privacy, and about the crusade by a family to have their ancestor’s contribution to medical science recognized…to have Henrietta memorialized not just as a one-of-a-kind aggregate of genetic material but as a woman.

Read this brilliant bestseller. 

It is hard to believe that Matt Ridley’s grand tour of the human genome was published back in 1999. Yet even today, more than two decades later, Ridley’s engaging, chromosome by chromosome investigation of our genetic make-up remains a marvel that has never been equaled. From the genes that enable the most basic chemical processes in our cells to those that determine our height and eye color, the mysterious “junk DNA” that lives between our genes, and speculation about the ways that genes affect personality, behavior, and society, Ridley brings science to life in this engaging and timeless book.

I was familiar with the theory of evolution when I read this book several decades ago, but it deepened my understanding, and I also liked Dawkins’s writing style. The most impactful insight was the role of spontaneous replication. As humans we replicate with a purpose, but that does not diminish the impact of purposeless replication of the simpler units that make us, such as our genes. The book explains how spontaneous replication of random mutations results in the dominance of new organisms that are better adapted to a changed environment. This insight and my familiarity with physics and math helped me understand that everything in nature evolves by trial and error—from the physical processes that create order out of quantum chaos, through evolution in biology, to how humans learn and think.   

Before the coronavirus pandemic, Quammen investigated the science behind “spillover”—the way that animal illnesses can mutate and infect humans. Given the grim subject matter, I found this nonfiction account of various diseases to be surprisingly engrossing and highly readable. Spillover was one of my inspirational resources when I created my fictional illness for my novel. Quammen shares information about Ebola, SARS, Lyme disease, AIDS, bird flu, and others in this well-researched book.

I think I’m on my third or fourth copy of this book, because I keep giving it away! This is an absolutely stunning, gorgeously illustrated book about the spacesuits worn by Buzz Aldrin and Neil Armstrong during the moon landing. The bid to design the suits was won by the Playtex Corporation—the lingerie company!—over a bunch of industrial materials suppliers, because Playtex knew how to design for the body in ways the other firms didn’t. The book is organized into twenty-one chapters, in homage to the twenty-one layers of the spacesuit, and it’s a thing of beauty. It weaves together the history of aeronautics, the politics of the Space Race, technology design, and mid-century fashion so seamlessly, and makes you think about each of these topics differently.

Everyone who knows me has at some point had to hear me recount at least one anecdote from this book! Dundes was a professor of folklore, and this book is about all the ways Orthodox Jews navigate the prohibitions of the Sabbath. It includes a lot of incredible history about how technology plays a role in helping people do what they need to do without technically breaking the rules—like the Shabbat elevator in the title, which stops automatically at every floor in a building so that observant Jews don’t have to press a button to operate the elevator (which is prohibited). This book changed how I think about automation, and it’s so richly and respectfully written. One of my all-time favorites.

A book about pencil-and-paper baseball scorekeeping might seem like an odd one to include on a list about technology! But that’s precisely the point: even though by-hand scoring seems like an unnecessary relic in the digital age, this book so beautifully explains why people do it anyway, and how much richness and storytelling and personality there can be in a practice that, at first glance, seems like it might just be rote transcription. Recording data isn’t a science—it can be an art, a tradition, and a joy unto itself.

My copy of this book has so many dog-eared pages and “!”s scrawled in the margins that it’s almost ridiculous. This is the story of how, in the 1960s, New York City and the RAND Corporation used algorithmic modeling to decide where to locate fire stations in the city. It was pretty much a disaster: because of the choices the modelers made about what to measure and how to measure it, they ended up cutting services to many of the poorest neighborhoods in NYC. Joe Flood is a journalist, and it shows—this book is stunning in how it combines the stories of human beings with crystal-clear accounts of the technical decisions made by the computing “whiz kids.”

This might not look like a big data book but, for me, the race to read the human genome marks the birth of big data in biology, in the form of a tsunami of DNA sequencing data. I edited Craig Venter’s A Life Decoded, the first genetic autobiography, which explored the implications of becoming the first person to gaze upon all six billion ‘letters’ of their own genetic code. While working on Craig’s extraordinary story I came across The Genome War and thought James Shreeve did a brilliant job in describing the drama, rivalry, and personalities in the race to sequence the very first human genomes between government-backed scientists and Celera, Craig’s company.

This book explains in a wonderful language how we became the humans we are, from the roots in Africa to the spreading across continents. It even reconstructs the genetic fingerprints of Tschingis Kan in the modern human genome along his war routes. From DNA recovered from bones we also learn how waves of migrations with associated pandemics replace one continental gene pool with another one, and how the Americas were inhabited. Every educated person can understand this book. Truly eye-opening.