100 books like No Time to Lose

As a historian, some books just keep coming back to you. McNeill’s Plagues and Peoples is just such a book. 

He is really the first historian to outline the dramatic impact that infectious diseases have had on human history. He outlines the spread of smallpox, diphtheria, Yellow Fever, Malaria, the Plague, and many others, as they originate mostly in Africa and come into the Mediterranean Ocean, to produce cycles of death. 

But the people who lived on the edge of that ocean soon came to develop antibodies, and ultimately, master the impact of such terrible diseases.  

Unfortunately, those diseases were soon transferred to the Americas, where perhaps a hundred million American Indians died from them. They had no immunities!

Had such a calamity not occurred, the two western hemispheric continents might easily be dominated by Natives, who spoke a different language and prayed to a different God.

Scientists now know that the AIDS virus, HIV-1, entered the human population much earlier than is commonly thought—back around 1908, give or take a margin of error, and via a single spillover from a chimpanzee into a human, probably by blood exposure when a chimp was killed and butchered for food. Pepin’s book illuminates how the virus might then, slowly and quietly at first, have spread from a forest in southeastern Cameroun, down tributaries of the Congo River to major cities such as Brazzaville and Leopoldville (now Kinshasa), and from there to the world. Pepin’s work was vastly helpful to me when I assembled my own account of that story, included in my own books.

Charlie Calisher is a veteran in the field of killer viruses transmitted by mosquitoes and other arthropods, retired now after decades of dangerous work for the CDC, in collaboration with the WHO, and at Colorado State University. He’s also a sly, plainspoken curmudgeon with a golden heart, a piquant sense of humor, and a wonderfully easy way of telling the stories of science in a conversational tone. The fact that he has honored me with his friendship, and been an invaluable counsel to me and to others on the subject of viruses, biases my high opinion of this book practically not at all.

Into the deep weeds, for those who dare! Eddie (as he is famously known) Holmes is one of the world’s leading experts on molecular evolutionary virology, particularly regarding the RNA viruses—which are the scariest and most menacing ones, the ones that mutate often, evolve fast, and spill over from animals to cause gruesome new diseases in humans. Ebola. Marburg. Nipah. Hendra. SARS-1. MERS. Zika. The dengues. And of course SARS-CoV-2, the COVID-19 beast. Eddie Holmes explains, in lucid but authoritative prose, where these creatures come from, how they adapt so well to infecting people, and why RNA virology is a crucial survival tool for the human future.

I’m going to say right off the top that this book is not well written: it’s turgid and florid and hard to follow. But it’s also recent, unlike most of the books on my list, and it’s the first comprehensive accounting of PEPFAR, the extraordinary US intervention into the African pandemic.

It’s impossible to understand the huge shift in the dynamic of the pandemic without understanding how massively George Bush’s decision to support HIV treatment in Africa changed – well, everything – and Bass is the first writer to try to really dig into that story.

Craig Timberg was a reporting colleague when I was a correspondent in South Africa, and became a friend, one with whom I often passionately disagreed.

That’s why I suggest this book: it offers a very different perspective than mine. Craig and his co-author Halperin, an epidemiologist whose work had a big influence on Craig’s thinking, draw a clear through-line for how Western powers created the sparks of the African epidemic then vigorously fanned them.

A significant chunk of the book focuses on solutions (Halperin is a vociferous champion of male circumcision as an intervention to drive down the spread of the virus). It’s a brisk read that makes complex epidemiological dynamics accessible.

Eben Venter, though born in the heart of the South African ‘platteland’ (the South African equivalent of ‘fly-over country’), has spent much of his adult life in Australia, and the novel poignantly straddles the two locales: the constricting conservatism of the protagonist’s farm background, and the bewildering freedoms and opportunities of a more cosmopolitan setting. Here that conflict is heartbreakingly acted out and in a grim sense resolved in the main character’s losing battle against AIDS, and his death-bed reconciliation with his hitherto unbending father. Venter gives us a harrowing account of what it is like to die of a disease that wastes your body, blinds you, and makes you mad before killing you. It is all the more remarkable that the experience is registered from the inside, as it were, in a subjective stream of consciousness. The poignancy of the novel is intensified for me by knowing that the… show more.

I may be a bit biased on this one since Dr. Goldstein is one of my mentors, but this book really shows the power that narrative has when it comes to understanding illness and assessing risk.

Once Upon a Virus very clearly helps us understand why looking at disease and illness from the standpoint of the community is so important. If we want to promote any type of health behavior or change, we must adapt to the specific community instead of expecting the community to change.

Listening to these stories is crucial for public health and I really wish more people would read this book and understand that!

This is a memoir that has really stayed with me. It is beautifully written and a compulsive read.

Dr. Verghese describes the world of the deep south on the precipice of the AIDS epidemic. It is his story of being a young doctor, but also the story of the explosion in HIV cases far from the coastal cities that were the epicenters of the epidemic. I found myself crying over the cases he described, and feeling his heart-ache as he battled for individuals with HIV to gain acceptance, support, and treatments in their communities. 

Oh, Was, how I love your relentlessly bleak, depressing sadness.

This is a strangely inventive novel that twines reality and fantasy into a brutal, desolate, yet gorgeous story of pain and survival. Told from the points of view of numerous characters, each story is tethered in some way to The Wizard of Oz, that venerable fable about good versus evil in the search for home.

Ryman introduces us to a main trio of characters whose lives are all equally harrowing–Dorothy Gael (the imagined inspiration for The Wizard of Oz heroine and the victim of familial sexual abuse), Frances Gumm (who becomes the tragic Judy Garland), and Jonathan (an actor experiencing AIDS-related dementia)–whose stories he intricately weaves together like a master craftsman. And while the novel is not a “happy” read by any stretch of the imagination, what has stayed with me throughout the past thirty years is its… show more.