100 books like Great and Desperate Cures

One of Oliver Sack’s delightful books containing stories of individuals with various neurological disorders. I read the first one, The Man Who Mistook His Wife for a Hat, back in the 1980s  when it first came out and was hooked, now having read almost all of them.

The one I am recommending is, I believe, more relevant to an understanding of brain mechanisms. One criticism I have had of Sack’s books is that there is little in the way of neurobiological explanations for the conditions described. In my book, most chapters begin with a Sack-like story about a specific neurological condition that is then explained, as far as possible, neurobiologically in the chapter.

Although this book has been around for a very long time, I only encountered it earlier this year.

It is a scientific fiction novel based on a supposed treatment given to a mentally handicapped young man (Charlie) that gave him great intelligence. This treatment had been tried earlier on mice (one being Algernon), enabling them to do cognitive tasks impossible for ordinary mice. The basis for much of the book was that the treatment was not permanent, and first, Algernon and then Charlie deteriorated back to where they were cognitively before the treatment.

The book beautifully describes what it was like (in Charlie’s own words) to be cognitively disabled before the treatment and how he was treated by people; then, when the treatment was effective, and finally, as he was deteriorating, which he recognized was happening. Although fictional, the descriptions of the cognitive changes in Charlie are compelling.

One of the world’s best neuroscientists, who won the Nobel Prize in 2000, engagingly describes neurological and cognitive diseases/conditions and how they can be debilitating but, in some cases, can lead to extraordinary mental abilities in memory, visual arts, etc.

It came out the same year as my book, and it adds to and complements it. I found the descriptions of brain disorders compelling and the history of psychiatry woven into the chapters fascinating. The relationship between certain cognitive disorders and highly creative people is discussed, and an intriguing reason for this is proposed.

I very much enjoy reading biographies and autobiographies about scientists. My favorite is Cajal’s autobiography.

Cajal is considered by many to be the Father of Neuroscience. He grew up in Spain, where he lived his entire life. He loved to draw and wanted to become an artist, but his father discouraged this, so he went to medical school. He used his artistic skills to great advantage when he began to study the brain and its cells. His drawings are meticulous, exceptionally accurate, and have never been surpassed.

Virtually every book on neuroscience includes some of his drawings. This book recounts not only his scientific career but also other of his fascinations. He loved chess and played it with individuals all over the world, but he gave it up because it was taking up too much of his time.

The Tale of the Dueling Neurosurgeons is a fun, engaging, and well-written introduction to your brain and some of the most interesting characters in the history of neuroscience.

Sam Kean is an excellent science writer—the type who draws you in so much with his storytelling that you forget you’re actually learning something. By the end of this book, you’ll know more about how the brain works, but perhaps better yet you’ll have enjoyed an array of colorful historical tales that explain how our knowledge of the brain has advanced over the years.

There is nothing more satisfying than a well-researched story about the history of medicine. 

This shocking story takes place in the mid-twentieth century and centers on Ruth, a hospital administrator whose husband invented the ice pick lobotomy for the treatment of psychiatric illness. As the surgery gains popularity, Ruth soon learns of debilitating complications from the procedure. Could the touted miracle cure be doing more harm than good?

This book offers a captivating tale of how the increasing knowledge of one disease, syphilis, created the foundations to understanding that the brain and mind are one and the same. The authors narrate the stories of patients whose “hysteria” (today referred to as functional neurological disorder) were traced to degenerative brain lesions that only belatedly were understood to be complications caused by remote infections with the bacterium Treponema pallidum. Several chapters follow the story of the important characters depicted by André Brouillet in the Une leçon clinique à la Salpêtrière (A Clinical Lesson at the Salpêtrière), one of the most recognized paintings by neurologists, as it depicts Jean-Martin Charcot, shown among many of his disciples, demonstrating a “hysteric” seizure in one of his patients. The authors illustrate how we have gotten away with conceptualizing behaviors without biological basis and put the reader on notice that “mental illnesses” are neurological problems… show more.

I truly loved this book because Dr. Daniel Amen is the best in his class. He is a dedicated brain scientist, author, and life changer. I’ve read all of his books because they teach us all how to benefit our brains to change our lives forever.

This book has helped me personally, and so has his research. He's a personal friend and one hell of a game-changer when it comes to recognizing the importance of altering the conversation from mental health to brain health.

He is an important figure of this or any time; the world is lucky he's here to make us all better, one brain at a time. 

We neuroscientists know a lot about how brains are, but not how they come to be. This book fills that huge hole: it explains how genetics and development shape the growing brain, and the consequences this has for our personalities and our mental disorders. Mitchell’s thesis is that the stochastic nature of development is key to understanding much of the variation between brains, and it has changed the way I think about the wiring of brains.

Geoff Herbach is the award-winning author of YA books. His latest, Cracking the Bell, deals with a major issue in contact sports—concussion. After several years of online writing with him, we met in person at a big mystery convention. A college professor in Minnesota, Land of a Thousand Lakes, he has produced radio comedy shows and toured rock clubs telling weird stories. 

When the main character, Isaiah, is knocked out on the field, the consequences reach far beyond his ability to play, forcing him to think about life with football. He has to consider tough decisions that will have an impact on his family, his team, and his future. How do you decide your path to the future when none of your choices are good?