Here are 33 books that Breakthrough fans have personally recommended if you like
Breakthrough.
Shepherd is a community of 12,000+ authors and super readers sharing their favorite books with the world.
I’ve been passionate about science as a way of learning how nature works and approaching truth since I was a pre-teen. After five decades of basic research, teaching, and management in physics, I can distinguish good science from pseudoscience even beyond my own areas of expertise. I am greatly disturbed by attempts to undermine science in public policy-making when its findings conflict with ideology, religious beliefs, or business bottom lines. My passion project, via my blog debunkingdenial.com, is to explain to teachers and the public the underlying science and the flaws in science denial across a wide range of topics at the interface with public policy.
I love this book because it turns the most impactful science discovery of the 21st century–CRISPR gene editing–into a page-turner. Isaacson combines a biography of Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier, with lucid accounts of the science and sequence of research breakthroughs that underlie CRISPR editing, as well as the intrigues and jockeying among powerful scientists and personalities vying for prizes and patents on the technology.
I came through this book to appreciate the enormous potential of CRISPR gene editing for good (curing hereditary diseases) and not-so-good (designer babies or, in the words of Vladimir Putin, “a soldier, an individual who can fight without fear or compassion, mercy or pain”). CRISPR promises to make human selection as important as natural selection in the evolution of many species, including humans.
The best-selling author of Leonardo da Vinci and Steve Jobs returns.
In 2012, Nobel Prize winning scientist Jennifer Doudna hit upon an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA.
Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.
But what does that mean for humanity? Should we be hacking our own DNA to make us less susceptible to disease? Should…
As a physician, medicine is my job. But along the way, I wondered how medicine got to where it is now–like really wondered. I wondered to the point that I was reading the original treatises written by 18th-century physicians. I started publishing research on medical history and giving presentations at medical conferences. I’d like to think this helps me be a better doctor by broadening my perspective on the healthcare industry. But at the very least, I’ve found these books enjoyable and compelling. I hope you enjoy them, too!
I re-read this book anytime I want a greater appreciation for living in the 21st century because it is teeming with downright disgusting medical stories from the 1800s–and it’s fantastic.
Our healthcare system is nowhere near perfect, but the juxtaposition between it and the gory details of pre-anesthetic and pre-antiseptic surgeries makes me so incredibly thankful.
Winner, 2018 PEN/E.O. Wilson Prize for Literary Science Writing Short-listed for the 2018 Wellcome Book Prize A Top 10 Science Book of Fall 2017, Publishers Weekly A Best History Book of 2017, The Guardian
"Warning: She spares no detail!" —Erik Larson, bestselling author of Dead Wake
In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of nineteenth-century surgery and shows how it was transformed by advances made in germ theory and antiseptics between 1860 and 1875. She conjures up early operating theaters—no place for the squeamish—and surgeons, who, working before anesthesia, were lauded for their speed and…
I’m a surgeon who loves history. I always have. I studied military history in college but decided to become a doctor because I also love helping people. In my medical training I marveled at the incredible treatments and operations we use to save lives and always felt the unsung heroes who gave us these miracles deserve to be better known. That’s why I wrote this book.
Bliss’s classic book is the definitive account of the discovery of insulin by Canadians Frederick Banting, Charles Best, J.R.R. Macleod, and James Collip. I share this story in my book but Bliss delves far deeper into this incredible tale full of drama and human failings.
Bliss describes Banting as a failed surgeon who had a middle-of-the-night epiphany about how to isolate the unknown product of the pancreas’s mysterious islets of Langerhans cells. Eminent scientist Macleod gives Banting a chance and some lab space, but in the end, Banting accuses Macleod of stealing credit for this discovery that turns diabetes from a death sentence into a chronic, manageable illness.
Banting loathes Macleod so much that he almost refuses his Nobel Prize because he is so angry that Macleod will also get one!
When insulin was discovered in the early 1920s, even jaded professionals marveled at how it brought starved, sometimes comatose diabetics back to life. In this now-classic history, Michael Bliss unearths a wealth of material, ranging from the unpublished memoirs of scientists to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a long-standing controversy that dates back to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the prize with an additional associate, medical opinion was intensely divided over the…
I’m a surgeon who loves history. I always have. I studied military history in college but decided to become a doctor because I also love helping people. In my medical training I marveled at the incredible treatments and operations we use to save lives and always felt the unsung heroes who gave us these miracles deserve to be better known. That’s why I wrote this book.
The discovery of penicillin is one of humanity’s greatest stories of serendipity and Eric Lax’s retelling is excellent.
Though Alexander Fleming has received the lion’s share of the credit for this discovery, in truth, Howard Florey, Ernst Chain, and Norman Heatley were the ones who discovered and proved the penicillium mold’s true medical effectiveness as an antibiotic.
How this trio from Oxford made their breakthrough at the height of WWII and were robbed of the credit is a fabulous tale as spellbinding as any Hollywood movie.
The author of Life and Death on 10 West chronicles the fascinating true story of the Oxford scientists who discovered penicillin by experimenting on mold, creating a family of drugs that would eradicate some of the worst diseases in human history. Reprint. 35,000 first printing.
Michael B.A. Oldstone was head of the Viral-Immunobiology Laboratory at The Scripps Research Institute, devoting his career to understanding viruses, the diseases they cause, and the host’s immune response to control these infections. His work led to numerous national and international awards, election to the National Academy of Science and the National Academy of Medicine. Oldstone served on the SAGE executive board of the World Health Organization and as a WHO consultant for the eradication of polio and measles.
In a clear presentation, Oshinsky’s presents the gripping history of the conquest of poliomyelitis. The new and advanced role of the media’s impact and widespread community participation is detailed as is the terror of polio, efforts to understand the virus, and the disease it caused. The intense and competitive effort to find a cure adds to the story. Lastly, this book describes how the polio experience led to the establishment of government oversight for new drugs.
All who lived in the early 1950s remember the fear of polio and the elation felt when a successful vaccine was found. Now David Oshinsky tells the gripping story of the polio terror and of the intense effort to find a cure, from the March of Dimes to the discovery of the Salk and Sabin vaccines-and beyond. Here is a remarkable portrait of America in the early 1950s, using the widespread panic over polio to shed light on our national obsessions and fears. Drawing on newly available papers of Jonas Salk, Albert Sabin and other key players, Oshinsky paints a…
I'm an architect, professor, and director of the School of Architecture at the University of North Carolina at Charlotte. Throughout my career, I've sought to empower people to improve the designed environment through better knowledge of materials. I've written nine books and many articles on emerging materials, sustainable building technologies, and Japanese architecture and design. Having lived in Japan several times, I also appreciate the importance of developing an expanded worldview of material practices.
A visit to the Salk Institute in La Jolla, California, is on most architects' bucket lists.
The virologist Jonas Salk, who commissioned architect Louis Kahn to design the significant project, is best known for developing one of the first successful polio vaccines. Less familiar is this remarkable book, which Salk wrote with his son Jonathan, that explores the future of human societies.
By applying scientific principles about how organisms respond to resource limitations, the authors project the significant resource challenges and opportunities that await future human generations. The book looks beyond the population explosion to explore its mysterious aftermath. Indeed, the transition is already underway.
A New Reality: Human Evolution for a Sustainable Future provides a startling, fresh new message of understanding, perspective and hope for today’s tense, rapid-fire, kaleidoscopically changing world.
Drawn from the writings of visionary scientist Jonas Salk, who developed the polio vaccine, and extended and developed by his son Jonathan, the message of A New Reality explodes from the past, and sheds light on tensions that besiege us, and the currents of discord that are raging as these words are written. More importantly, it indicates a way forward out of our current situation.
Throughout my life, I have been fascinated by humanity’s place within deeper time. As a boy, I collected rocks and fossils, and at university studied geology. The long term has also been a theme running throughout my journalism career at New Scientist and the BBC, and it inspired my research during a recent fellowship at Massachusetts Institute of Technology in the US. I believe we need to embrace a deeper view of time if we are to navigate through this century’s grand challenges – and if we can, there’s hope, agency, and possibility to be discovered along the way.
The concept of the ‘good ancestor,’ originally coined by physician Jonas Salk, is the focus of Roman Krznaric’s excellent book about our relationship with future generations.
I’ve known Roman for a few years now: he spoke about long-term time on a panel I organised at the Hay Festival a few years ago, and he makes an appearance in my own book on a trip we both made to the House of Lords to watch a debate about future generation policy.
He is a crystal clear thinker and communicator, and I’ve learnt a lot from him. One of the most interesting (of many) ideas in his book is the idea that we are “colonising” the future: treating it as some distant no-man’s land where we can dump environmental degradation, malignant heirlooms, carbon emissions, and so on.
Of course, the future belongs to the people living there: our grandchildren. Roman makes a…
'This is the book our children's children will thank us for reading' - The Edge, U2
How can we be good ancestors?
From the first seeds sown thousands of years ago, to the construction of the cities we still inhabit, to the scientific discoveries that have ensured our survival, we are the inheritors of countless gifts from the past. Today, in an age driven by the tyranny of the now, with 24/7 news, the latest tweet, and the buy-now button commanding our attention, we rarely stop to consider how our actions will affect future generations. With such frenetic short-termism at…
I was drawn into the study of medieval history through an interest in chivalry and this led to a PhD and various publications on the career and household of Edward the Black Prince (1330-76). He lived through the heart of what’s become known as the late medieval crisis: a period which many contemporaries thought was a prelude to the apocalypse. I’ve been teaching and writing about this period for more than 20 years now and remain fascinated by the contrasts between creativity and utter devastation that characterise the later middle ages.
This is a wonderfully curated selection of sources drawn from many western European countries. They offer us a real sense of how individuals, groups, governments and the Church reacted to this, perhaps the most appalling natural disaster in European history. We learn not only of political but personal and psychological reactions to a plague which most contemporaries viewed as a manifestation of divine anger with a sinful world.
This series provides texts central to medieval studies courses and focuses upon the diverse cultural, social and political conditions that affected the functioning of all levels of medieval society. Translations are accompanied by introductory and explanatory material and each volume includes a comprehensive guide to the sources' interpretation, including discussion of critical linguistic problems and an assessment of recent research on the topics covered.
From 1348 to 1350 Europe was devastated by an epidemic that left between a third and one half of the population dead. This source book traces, through contemporary writings, the calamitous impact of the Black Death…
I began college as a science major, but then switched to literature from a minor to my major. In graduate school, as I worked on my dissertation (which became my first book), I found that metaphors of the body and health were everywhere in the literary field in the mid-nineteenth century. Suffice it to say that the sciences, including the rapid development of modern medicine, are both fundamental to this period and deeply shape its literary culture. In Mapping the Victorian Social Body, I became fascinated with the history of data visualization. Disease mapping completely transformed the ways we understand space and how our bodies exist within it.
This collection of previously published essays by Charles Rosenberg elaborates many of his ideas about how people make meaning out of epidemics, including his famous theory that epidemics are understood in a dramatic tripartite structure (see “What Is an Epidemic? AIDS in Historical Perspective”). Rosenberg shows not only how the history of medicine illuminates larger themes, but why it matters, both to those of us interested in history and those interested in medical science itself.
Medicine has always had its historians; but until recently it was a history written by and for practitioners. Charles Rosenberg has been one of the key figures in recent decades in opening up the history of medicine beyond parochial concerns and instead viewing medicine in the rich currents of intellectual and social change of the past two centuries. This book brings together for the first time in one place many of Professor Rosenberg's most important essays. The first two sections of essays, focusing on ideas and institutions, are meant at the same time to underline interactions between these realms. The…
I’m reading books that are centered on science and behavior and health. After decades of research on the interplay between genes and the environment, I had a strong foothold on the genetic part, but I needed to understand the environment part to make any sense of it all. This research has broadened my horizons exponentially. We know that genes are immutable, for the most part… but parts of the genome are mutable—and we can shape our lifestyle/behavior to improve our health.
Like the author, I spent decades studying the interplay of genes and the environment. His focus is behavior, while mine is cancer—and, more recently, lifestyle and behavior, since many chronic diseases are heavily influenced by the environment.
Making science, philosophy, and the history of medicine accessible to the average reader, Sapolsky argues that our decisions are influenced by “biology” writ large.
One of our great behavioral scientists, the bestselling author of Behave, plumbs the depths of the science and philosophy of decision-making to mount a devastating case against free will, an argument with profound consequences
Robert Sapolsky’s Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but that doesn’t mean it doesn’t exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and…
