100 books like The Discovery of Insulin

I love this book because it turns the most impactful science discovery of the 21st century–CRISPR gene editing–into a page-turner. Isaacson combines a biography of Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier, with lucid accounts of the science and sequence of research breakthroughs that underlie CRISPR editing, as well as the intrigues and jockeying among powerful scientists and personalities vying for prizes and patents on the technology.

I came through this book to appreciate the enormous potential of CRISPR gene editing for good (curing hereditary diseases) and not-so-good (designer babies or, in the words of Vladimir Putin, “a soldier, an individual who can fight without fear or compassion, mercy or pain”). CRISPR promises to make human selection as important as natural selection in the evolution of many species, including humans.

I re-read this book anytime I want a greater appreciation for living in the 21st century because it is teeming with downright disgusting medical stories from the 1800s–and it’s fantastic.

Our healthcare system is nowhere near perfect, but the juxtaposition between it and the gory details of pre-anesthetic and pre-antiseptic surgeries makes me so incredibly thankful. 

This fantastic biography recounts one of the greatest rivalries in medical history during the race for the polio vaccine, which pitted Jonas Salk and Albert Sabin against each other.

Salk favored a killed-virus approach, which was easier but perhaps less protective and long lasting. Sabin preferred an attenuated-virus method that was more difficult to make but could be life-long and delivered orally rather than by serial injections.

Salk’s vaccine arrived first and saved thousands of lives, but Sabin still publicly criticized it, even in testimony to Congress. Sabin’s vaccine later became favored, but the debate about whose was superior persisted and continued long after each man’s death.

Carter’s superb narrative benefited from his weeks-long interviews with Salk, and interviews with other major figures in the effort to defeat polio.

The discovery of penicillin is one of humanity’s greatest stories of serendipity and Eric Lax’s retelling is excellent.

Though Alexander Fleming has received the lion’s share of the credit for this discovery, in truth, Howard Florey, Ernst Chain, and Norman Heatley were the ones who discovered and proved the penicillium mold’s true medical effectiveness as an antibiotic.

How this trio from Oxford made their breakthrough at the height of WWII and were robbed of the credit is a fabulous tale as spellbinding as any Hollywood movie.

The discovery of insulin in early 1922 was a medical milestone that has since saved countless lives–my own included. Until this moment, a diagnosis of Type 1 Diabetes was a certain death sentence. But as diabetes clinician and historian of medicine, Chris Feudtner points out, the success of insulin has distorted historical accounts of diabetes by marginalising the experience of the patient in favour of narratives that focus on the development of medical technology to treat them. And Feudtner’s diagnosis is confined not just to diabetes but to the history of medicine in general. Following a personal epiphany that patients have an existence beyond X-rays and blood tests, Feudtner set out to address this problem by writing a history of diabetes as told from the perspective of patients. He does so magnificently and offers important insights about our relationship with technology that extend well beyond the treatment of diabetes.

After a cancer diagnosis, it is natural to wonder what causes cancer. Our understanding of cancer etiology continues to evolve as the science of genetics deepens. The Cancer Code reviews this research in laymen’s terms such that each reader can construct a narrative about what factors may have contributed to their illness. A successful cancer patient is an informed cancer patient, navigating the system with an appreciation for why some standard of care therapies are more effective than others. This book allowed me to look under the hood of cancer in a way that guided my decisions before and after remission.

‘Counting’ calories at every meal is not a recipe for a sane or happy life. But knowing the approximate calorie content of what you regularly eat is certainly wise. This is a look-up book, not a reading book. So—how about the blueberry muffin you have been led to believe is the healthy option? What! 393 calories? But that is about a quarter of the daily calorie requirement for a smaller person. Orange juice? Ah yes, one of my five-a-day—so healthy. But at 90 calories per 250 ml glass it is easy to cut without bothering appetite. Taken in addition to a weight neutral diet, it would cause around six pounds of weight gain in a year. This is a book of information. Information useful for life. 

This book by an award-winning Canadian novelist mixes memoir and essay. The memoir is set in New Brunswick’s Miramichi region in 1961. Richards has no use of his left arm; his best friend is going blind due to diabetes. They are in their last year of playing hockey. Woven into that story are other memories—including of distasteful meetings with people who don’t like the sport—as well as his thoughts on the game and its place in the Canadian psyche. Hockey Dreams is highly personal, so it may not be for readers, but I loved it. 

Mastering Diabetes explains the nature of the disease, and why the standard treatment of Type 2 Diabetes in particular is counterproductive. The authors draw from their own personal experience and the experiences of those they have counseled, but they provide evidence from a raft of scientific studies. They have had striking success, which they report with energy and enthusiasm. With confidence born of that success, they stand conventional diabetes wisdom on its head.

Perry has created two great characters in Aidan and Kate. Both are damaged in their own ways – Kate has diabetes and Aidan lost an arm in Afghanistan - and certain their problems are the only things that define them. Watching them grow and change and accept that they are so much more than their problems makes this a satisfying read.