100 books like The Discovery of Insulin

I have seldom read a book with as much zeal as The Code Breaker, written by the famous biographer and historian, Walter Isaacson, whom I’d met on the CRISPR conference circuit.

Isaacson focuses on Doudna’s life and science, but also introduces the reader to a large cast of characters, including Doudna’s former colleague and fellow Nobelist, Emmanuelle Charpentier. He even has a crack at running a CRISPR experiment himself.

The success of this book has likely done more than anything to educate the public on the transformative promise of CRISPR.

Fitzharris’s book is a page-turner that takes readers into the macabre operating theaters of the Victorian era, when surgeons rarely washed their hands or cleaned their scalpels, anesthesia did not exist, and the “best” surgeons were simply those who worked the fastest.

Joseph Lister’s effort to convince the world of the merits of antisepsis is a true underdog story in which the stakes could not have been higher. 

This fantastic biography recounts one of the greatest rivalries in medical history during the race for the polio vaccine, which pitted Jonas Salk and Albert Sabin against each other.

Salk favored a killed-virus approach, which was easier but perhaps less protective and long lasting. Sabin preferred an attenuated-virus method that was more difficult to make but could be life-long and delivered orally rather than by serial injections.

Salk’s vaccine arrived first and saved thousands of lives, but Sabin still publicly criticized it, even in testimony to Congress. Sabin’s vaccine later became favored, but the debate about whose was superior persisted and continued long after each man’s death.

Carter’s superb narrative benefited from his weeks-long interviews with Salk, and interviews with other major figures in the effort to defeat polio.

The discovery of penicillin is one of humanity’s greatest stories of serendipity and Eric Lax’s retelling is excellent.

Though Alexander Fleming has received the lion’s share of the credit for this discovery, in truth, Howard Florey, Ernst Chain, and Norman Heatley were the ones who discovered and proved the penicillium mold’s true medical effectiveness as an antibiotic.

How this trio from Oxford made their breakthrough at the height of WWII and were robbed of the credit is a fabulous tale as spellbinding as any Hollywood movie.

The discovery of insulin in early 1922 was a medical milestone that has since saved countless lives–my own included. Until this moment, a diagnosis of Type 1 Diabetes was a certain death sentence. But as diabetes clinician and historian of medicine, Chris Feudtner points out, the success of insulin has distorted historical accounts of diabetes by marginalising the experience of the patient in favour of narratives that focus on the development of medical technology to treat them. And Feudtner’s diagnosis is confined not just to diabetes but to the history of medicine in general. Following a personal epiphany that patients have an existence beyond X-rays and blood tests, Feudtner set out to address this problem by writing a history of diabetes as told from the perspective of patients. He does so magnificently and offers important insights about our relationship with technology that extend well beyond the treatment of diabetes.

After a cancer diagnosis, it is natural to wonder what causes cancer. Our understanding of cancer etiology continues to evolve as the science of genetics deepens. The Cancer Code reviews this research in laymen’s terms such that each reader can construct a narrative about what factors may have contributed to their illness. A successful cancer patient is an informed cancer patient, navigating the system with an appreciation for why some standard of care therapies are more effective than others. This book allowed me to look under the hood of cancer in a way that guided my decisions before and after remission.

This book by an award-winning Canadian novelist mixes memoir and essay. The memoir is set in New Brunswick’s Miramichi region in 1961. Richards has no use of his left arm; his best friend is going blind due to diabetes. They are in their last year of playing hockey. Woven into that story are other memories—including of distasteful meetings with people who don’t like the sport—as well as his thoughts on the game and its place in the Canadian psyche. Hockey Dreams is highly personal, so it may not be for readers, but I loved it. 

Perry has created two great characters in Aidan and Kate. Both are damaged in their own ways – Kate has diabetes and Aidan lost an arm in Afghanistan - and certain their problems are the only things that define them. Watching them grow and change and accept that they are so much more than their problems makes this a satisfying read.

Every book by Annemarie Mol is good but The Logic of Care is simply the best book on what medicine should be. It is short, deceptively simple but leaves no hiding places. Everyone will be able to understand it in the same way from a teenager up through a Professor of Medicine to a Minister for Health but don’t expect any Ministers to admit to reading it any time soon. Mol outlines a relationship-based rather than technology-based medicine. How do we ensure medical techniques help us to live the lives we want to live rather than force us to live lives that suit the companies that make the technologies want us to live? How do we care for people rather than service them?

‘Counting’ calories at every meal is not a recipe for a sane or happy life. But knowing the approximate calorie content of what you regularly eat is certainly wise. This is a look-up book, not a reading book. So—how about the blueberry muffin you have been led to believe is the healthy option? What! 393 calories? But that is about a quarter of the daily calorie requirement for a smaller person. Orange juice? Ah yes, one of my five-a-day—so healthy. But at 90 calories per 250 ml glass it is easy to cut without bothering appetite. Taken in addition to a weight neutral diet, it would cause around six pounds of weight gain in a year. This is a book of information. Information useful for life.