Here are 100 books that Malignant fans have personally recommended if you like
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Frank S. David, MD, PhD leads the biopharma consulting firm Pharmagellan, where he advises drug companies and investors on R&D and business strategy. He is also an academic researcher on strategy, regulation, and policy in the drug industry; a member of the Harvard-MIT Center for Regulatory Science; and a former blogger at Forbes.com.
This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.
I am the former president of Pfizer Global Research, where I led research groups around the globe in finding new medicines to treat cancer, addiction, AIDS, immunological diseases, and pain. After retiring from Pfizer, I have been closely involved with biotech companies that also are seeking breakthrough drugs. This industry is a crucial part of the healthcare ecosystem, as evidenced by the remarkable response and, ultimately, the crushing of the COVID-19 pandemic. Yet, it is not just underappreciated but is treated with scorn by many. This booklist provides sources from which the reader can gain a full understanding of the value of the biopharmaceutical industry, the challenges it faces, and its importance to the world’s health.
Legislators and healthcare insurers are seeking ways to slash healthcare costs, often focusing on cutting the costs of medicines through schemes like price controls. Yet, drugs make up only about 13 percent of the money paid on healthcare. This book does a great job of explaining what is behind the pricing of new drugs but, more importantly, shows that all life-saving drugs eventually become low-cost generics – truly a Great American Drug Deal.
This book scrutinizes all players in the healthcare industry and offers new ideas for cost-saving measures, such as closing loopholes, dealing with bad actors, and educating consumers. If you want to understand how best to balance innovation and affordability, this book is a must-read.
Developing life-changing drugs is risky and expensive—but that’s not what makes them unaffordable.Drug pricing is a staple of every news cycle and political debate. And while we’ve struggled for decades to agree on solutions that serve all patients without jeopardizing the invention of new medicines, many Americans suffer because they can’t afford the drugs they need.Do we really have to choose between affordability and innovation?In The Great American Drug Deal, scientist and industry expert Peter Kolchinsky answers this question with a decisive No. The pharmaceutical industry’s commitment to creating new lifesaving drugs destined to become inexpensive generics can be balanced…
Frank S. David, MD, PhD leads the biopharma consulting firm Pharmagellan, where he advises drug companies and investors on R&D and business strategy. He is also an academic researcher on strategy, regulation, and policy in the drug industry; a member of the Harvard-MIT Center for Regulatory Science; and a former blogger at Forbes.com.
A key issue about drug pricing not covered in Kolchinsky's book relates to value: even if a new therapy is affordable, is it "worth it"? Health economist Peter Neumann and his colleagues have written an authoritative, insightful, and extremely accessible history of efforts to align drugs' prices with their benefits to patients and society. This is a must-read guide for both insiders and non-experts to a topic that will be at the forefront of the drug pricing debate in the coming decade.
The US prescription drug business is a $500 billion industry whose rising prices carry profound consequences for patients, caregivers, employers and taxpayers across the nation. In the United States, average prices of leading brand-name drugs are two to four times higher than prices charged in other wealthy countries, raising questions as to what Americans are getting for the extra expense. On the other hand, healthy industry returns have arguably fueled life-saving innovation. With the advent of ever more targeted and powerful treatments, including cell- and gene-based therapies with multi-million-dollar price tags, the need for sensible drug pricing policies will only…
My passion is life, hence why I became an environmental scientist, and why I became a conservationist at age 18, leading the campaign to protect Wollemi National Park in Australia. My sense of wonder towards nature has transformed my life. As Aldo Leopold observed, we ‘live in a world of wounds’ as the ‘more-than-human’ world is rapidly declining. But it doesn’t have to be this way, positive if challenging solutions exist. Hence why I write about environmental science, ecological economics, ecological ethics, denial, human dependence on nature, meaningful sustainability, and what we each can do to give back to Nature.
Soskolne edits one of the most important books on sustainability ever written, but written in a way the layperson can understand. It is over 400 pages long, but this is because it covers a multitude of deep topics by experts in the field. It is not waffle, does not indulge in denial, and is one of the most constructive books I have read that seriously addresses meaningful sustainability.
As global warming, famine, and environmental catastrophes have become daily news items, achieving a sustainable environment to maintain the future of life on Earth has become a global concern. Sustaining Life on Earth is an important contribution toward assessing such problems and making the Earth hospitable to life for generations to come. With an interdisciplinary team of international scholars, this masterfully edited collection approaches the problems facing sustainability from a perspective of global governance. To date, powerful economic forces have misguided decision-making processes in favor of short-term gain rather than long-term sustainability. As global awareness has increased and individual citizens…
As a feminist academic and activist, I am personally committed to the cause of reproductive freedom. Professionally, I've spent the past seven years carrying out research on abortion pills and their travels around the globe. This research involved more than eighty interviews with activists and doctors across the world, as well as analysis of many different text sources. My work has also taken me into activist spaces across Europe, as a volunteer with the Abortion Support Network. Although I entered the topic of reproductive rights through my interest in abortion, reading widely in the field has led me to pursue research interests in reproductive and biomedical technologies in other areas of sexual and reproductive health.
Dying to Count offers the very best of academic writing: the book makes a complex but persuasive argument, based on richly detailed fieldwork in Senegal. It shows the human consequences of anti-abortion laws, but it moves well beyond describing the experiences of women seeking abortion or the dilemmas of their doctors.
Women experiencing spontaneous miscarriage often have the same symptoms as women with complications from illegal abortions, and they often need the same medical treatment. So where abortion is illegal, Suh shows, classifying an abortion as a miscarriage can give women access to essential medical treatment. However, it can also freeze bad laws and policies in place, dampening efforts to legalize safe abortion.
Suh’s book shows how the best social science analysis can illuminate a subject in so many ways – from stories of individual patients in Senegalese hospitals, testimony from doctors and health workers, analysis of national and international…
During the early 1990s, global health experts developed a new model of emergency obstetric care: post-abortion care or PAC. In developing countries with restrictive abortion laws and where NGOs relied on US family planning aid, PAC offered an apolitical approach to addressing the consequences of unsafe abortion. In Dying to Count, Siri Suh traces how national and global population politics collide in Senegal as health workers, health officials, and NGO workers strive to demonstrate PAC's effectiveness in the absence of rigorous statistical evidence that the intervention reduces maternal mortality. Suh argues that pragmatically assembled PAC data convey commitments to maternal…
I’ve been writing, speaking, blogging, and tweeting about the history of American children and their childhoods for many decades. When I went to school—a long time ago—the subject did not come up, nor did I learn much in college or graduate school. I went out and dug up the story as did many of the authors I list here. I read many novels and autobiographies featuring childhood, and I looked at family portraits in museums with new eyes. Childhood history is fascinating and it is a lot of fun. And too, it is a great subject for book groups.
The Covid-19 pandemic makes this book a must-read as the author, reminds us that so many medications prescribed for children have not received all the tests for safety necessary to protect them. Yes, we got the heroin out of teething syrups, and our bottles now have child safety caps. Fun fact: the author you will learn, was as they put it at the time, an aspirin poisoned child thanks to those good-tasting baby aspirin. Shocking reality: pediatric drug research and regulation often follows disasters rather than preventing them. That’s why we, fortunately, have to wait for full testing before those covid vaccines get into the arms of the young. This book is an eye-opener.
Children and Drug Safety traces the development, use, and marketing of drugs for children in the twentieth century, a history that sits at the interface of the state, business, health care providers, parents, and children. This book illuminates the historical dimension of a clinical and policy issue with great contemporary significance-many of the drugs administered to children today have never been tested for safety and efficacy in the pediatric population.
Each chapter of Children and Drug Safety engages with major turning points in pediatric drug development; themes of children's risk, rights, protection and the evolving context of childhood; child-rearing; and…
I have an annoying habit of figuring out why someone says or believes what they do—and think that is more interesting than their actual ‘truth’. I try to keep this in check during social events (it can make for painful dinner table conversations if I go too far). Still, it means the general take on the medical humanities (and I’d put all the books below in that wide category) is something I’m passionate about. Why do we believe what we do about health? About disease? About the body? And why do we think medical doctors have the truth for us?
I don’t live in the USA, so the American debates about gun control and against universal health care often seem…odd. Why would someone think this is a bad thing? Metzl’s book gives at least one explanation.
Using interviews and observations, he shows how right-wing backlash policies are actually supported by people who are hurt by them because they appeal to a race-based sense of identity and privilege. This book was painful for me, but it explained some things that the news doesn't cover.
As Dying of Whiteness shows, the right-wing policies that resulted from this white backlash put these voters' very health at risk-and in the end, threaten everyone's well-being. Physician and sociologist Jonathan M. Metzl travels across America's heartland seeking to better understand the politics of racial resentment and its impact on public health. Interviewing a range of Americans, he uncovers how racial anxieties led to the repeal of gun control laws in Missouri, stymied the Affordable Care Act in Tennessee, and fueled massive cuts to schools and social services in Kansas. Although such measures promised to restore greatness to white America,…
I have long been drawn to everyday experiences in courts. Since Hurricane Katrina struck in 2005, I’ve been writing and teaching about courts, social welfare, and disasters in a changing climate. Following the disasters requires noticing the routine cases filed, not only the notable constitutional claims the United States Supreme Court hears. That can be hard to do, because all the cases filed are not listed in any one place. In the pandemic, my interest in the more ordinary met the databases that people assembled, gathering as best possible the many cases filed about the pandemic.
Sure, people objected to pandemic mitigation measures in other countries. Only in the United States were objections partisan.
This book elegantly relies on public opinion surveys to demonstrate the costs of partisanship in the pandemic. The authors discuss the economy, immigration, and voting. They document the Trump administration’s efforts to make mitigating the pandemic partisan. Masks are not inherently partisan. Our friends in medicine wear them all the time. In parts of Asia, many have used them to limit viruses’ spread.
Even before the pandemic, in the United States, partisanship had become at least as much about personal identity as policy differences. Every personal decision could signal partisanship. By meticulously capturing the pandemic and partisanship, the authors warn of the ongoing difficulties of managing disasters in a divided country.
How the politicization of the pandemic endangers our lives-and our democracy
COVID-19 has killed more people than any war or public health crisis in American history, but the scale and grim human toll of the pandemic were not inevitable. Pandemic Politics examines how Donald Trump politicized COVID-19, shedding new light on how his administration tied the pandemic to the president's political fate in an election year and chose partisanship over public health, with disastrous consequences for all of us.
Health is not an inherently polarizing issue, but the Trump administration's partisan response to COVID-19 led ordinary citizens to prioritize what…
We're all in this together: public health for all people, no matter their status or wealth, is one of humanity's great achievements. Favoring reason over faith, science over anecdote, and the group over the individual, has led to lowered infant mortality, improved health, and longer human lifespans. During pandemics, however, evidence and reason are often discarded, as people panic and try to save themselves. The odd human behavior we have seen during the Covid-19 pandemic has multiple precedents in the past. Quack cures, snake-oil sales, conspiracy theories, suspicion of authority, the emergence of cults with eccentric, bizarre, and inexplicable beliefs: again and again, this has been the human response to the unknown.
Laurie Garrett’s magisterial doorstop of a book is meticulously researched and compellingly written. Long before Covid, she made the case that our global public health systems, evolved over centuries and at their peak in the 1960s are now broken: under-funded, under-staffed, ill-prepared, and ill-equipped to handle a global pandemic. The Covid death count proved her right. She documents the political compromises and budgetary cutbacks made again and again that, for example, turned TB, once on the point of eradication, into the deadly multi-drug resistant (and in the case of XTB, totally resistant) scourge that infects billions planetwide. This is a grim, sobering book that made me pine for the days when the Surgeon General could say, without irony, that the age of infectious disease is over.
From the author of the New York Times bestseller, The Coming Plague, comes an explosive new work on a full-blown global health crisis in the making. Garrett takes readers around the world to reveal how a series of potential and present public health catastrophies mark the death of public health and taken together form a terrifying portrait of real global disaster in the making.
Public health is a bond between a government and its people and if either side betrays that trust the system is likely to collapse like a house of cards. Garrett illustrates how over the last twenty…
I am a journalist and author who has been lucky enough to follow my curiosity wherever it led – from politics and presidents to climate change and crime. Most of my books explore a theme that fascinates me – the tension between science and religion, faith and reason, that is a defining challenge of our era. I have a deep respect for science, but, like most, an amateur’s understanding of it. The global pandemic has confirmed the need for accessible science writing to help us bring our understanding in line with what’s going on in the labs.
Most of us can’t even pronounce the names of the childhood diseases vaccines have almost eradicated, nor can we imagine the parental grief, and childhood suffering, that those diseases routinely inflicted on families until well into the 20th Century. This comprehensive history reminds us that the development of vaccines was always a see-saw between life-saving advances, and terrible mistakes and failures.
Vaccine juxtaposes the stories of brilliant scientists with the industry's struggle to produce safe, effective, and profitable vaccines. It focuses on the role of military and medical authority in the introduction of vaccines and looks at why some parents have resisted this authority. Political and social intrigue have often accompanied vaccination-from the divisive introduction of smallpox inoculation in colonial Boston to the 9,000 lawsuits recently filed by parents convinced that vaccines caused their children's autism. With narrative grace and investigative journalism, Arthur Allen reveals a history illuminated by hope and shrouded by controversy, and he sheds new light on changing…
