Why am I passionate about this?
I spent my career in developmental biology: the science of how embryos develop. My main discovery was the discovery of one of the signals that controls development, called the fibroblast growth factor. Stem cell biology grew up on the basis of previous discoveries in developmental biology, and now, every day, people around the world use fibroblast growth factor among other substances to control the development of their stem cells. From 2007-2012 I was Director of the Stem Cell Institute at the University of Minnesota, so I got a good inside view of the whole field.
Jonathan's book list on stem cells from a scientist who studies them
Why did Jonathan love this book?
You don’t often get philosophers delving into the biomedical sciences. They mostly prefer physics and cosmology. But there are great pickings in the other sciences too!
Laplane considers the various proposed attributes of stem cells and classifies these as categorical, dispositional, relational, and system-based. She concludes that stem cells do comprise a "natural kind" i.e. a real thing, out there, not just a figment of our imagination. What emerges from this critical evaluation is that we should think not about stem cells as such but about stem-type behaviors that may be shown by various cell populations in specific circumstances. Defining stem cells is slippery and difficult, but defining stem cell behavior is relatively easy, and stem cell behavior is real and important.
1 author picked Cancer Stem Cells as one of their favorite books, and they share why you should read it.
An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.
Rather than treat cancer by aggressively trying to eliminate all cancerous cells-with harmful side effects for patients-CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells-the abilities to self-renew and to…