The best books on stem cells from a scientist who studies them

This book is much better than it looks at first sight. Although the “for dummies” theme might be off-putting to some, it is a serious account of stem cells with good scientific content. With 360 pages it has space to cover many topics and deals with the legal and ethical side of the field as well as the science and medicine. To me, it is perhaps a little too credulous about “miracle cells” that can turn into anything but is a lot less credulous than many other sources.

This is a beautiful book written by a great team from Utrecht in the Netherlands. It starts with a potted introduction to cell and developmental biology. I like this because, as a developmental biologist myself, I know that it is the basic science underpinning stem cell biology. It explains embryonic stem cells and cloning. Before covering transplantation therapy it explains about immune rejection of grafts and how this is dealt with. Unlike most books on stem cells, it covers non-therapeutic applications such as the study of human development or the use of stem cell-derived cells for safety testing of drugs.

The first and second editions had fabulous colour pictures all the way through. Sadly the 3rd edition has been downgraded to black and white.

This is a popular book, focusing on human interest but still scientifically reputable. Its main theme is the ethics, law, and politics of stem cells, mostly from a US perspective. It describes the debate in the USA about embryonic stem cells and how it polarized the nation. It covers many examples of political maneuvering to establish rules and regulations. It also has an international dimension and describes the legal position in countries around the world. I like it because I was in the USA during many of these debates and feel the book nicely captures the atmosphere of the controversy.

You don’t often get philosophers delving into the biomedical sciences. They mostly prefer physics and cosmology. But there are great pickings in the other sciences too! 

Laplane considers the various proposed attributes of stem cells and classifies these as categorical, dispositional, relational, and system-based. She concludes that stem cells do comprise a "natural kind" i.e. a real thing, out there, not just a figment of our imagination. What emerges from this critical evaluation is that we should think not about stem cells as such but about stem-type behaviors that may be shown by various cell populations in specific circumstances. Defining stem cells is slippery and difficult, but defining stem cell behavior is relatively easy, and stem cell behavior is real and important.

A little-known gem! Howard Green was a pioneer of research with stem cells from the skin. Back in the 1970s, he developed methods to grow them in vitro He went on to use this technology to enable treatment for very severe burns which covered too much of the body to make grafting feasible. The text is rather terse but this is a remarkable laboratory and clinical vignette from one who was there.