I’ve always been fascinated by the quest to understand how nature works and to find patterns amid complexity. This drew me towards physics, which seemed unparalleled in its ability to uncover general rules. In contrast, biology seemed merely descriptive, and despite a fondness for wildlife, I stayed away from the subject in school. It turns out, however, that physics and biology are perfect companions; a whole field, biophysics, explores how physical principles are central to the workings of living things. I became a biophysicist, researching topics like the organization of gut microbes and teaching and writing about biophysics more broadly, at scales from DNA to ecosystems.
I shouldn't admit this, but I've never found biochemistry at all interesting. I'm a biophysicist and routinely amazed by the versatility of physics and enchanted by the variety of biology. Lists of amino acids or the chemical reactions of the various types of sugars bore me to tears, though; I appreciate their importance, but I couldn't imagine studying them.
Therefore, reading this book was a revelation: Lane makes biochemistry seem sensible, deep, and fundamental, with rules and consequences central to life's origin. As an added bonus, Lane connects all this to vexing current problems, like the nature of cancer.
What brings the Earth to life, and our own lives to an end?
For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight -how the same simple chemistry gives rise to life and causes our demise.
Lane is among the vanguard of researchers asking why the Krebs cycle,…
I spent my career in developmental biology: the science of how embryos develop. My main discovery was the discovery of one of the signals that controls development, called the fibroblast growth factor. Stem cell biology grew up on the basis of previous discoveries in developmental biology, and now, every day, people around the world use fibroblast growth factor among other substances to control the development of their stem cells. From 2007-2012 I was Director of the Stem Cell Institute at the University of Minnesota, so I got a good inside view of the whole field.
A little-known gem! Howard Green was a pioneer of research with stem cells from the skin. Back in the 1970s, he developed methods to grow them in vitro He went on to use this technology to enable treatment for very severe burns which covered too much of the body to make grafting feasible. The text is rather terse but this is a remarkable laboratory and clinical vignette from one who was there.
In this book the author describes the discoveries in his laboratory that led to therapy with cultured cells. The first cultured cell type used for therapy was the keratinocyte of the epidermis, for the treatment of burns. Subsequent developments led to the use of cultured cells for the treatment of diseases of the eye, of the joints and of other diseases. Cultured cells for therapy are now being prepared by industries in the US, Japan and Korea and are used in the aforesaid countries, as well as in France, Sweden and Greece, for the treatment of disease.
I spent my career in developmental biology: the science of how embryos develop. My main discovery was the discovery of one of the signals that controls development, called the fibroblast growth factor. Stem cell biology grew up on the basis of previous discoveries in developmental biology, and now, every day, people around the world use fibroblast growth factor among other substances to control the development of their stem cells. From 2007-2012 I was Director of the Stem Cell Institute at the University of Minnesota, so I got a good inside view of the whole field.
This is a popular book, focusing on human interest but still scientifically reputable. Its main theme is the ethics, law, and politics of stem cells, mostly from a US perspective. It describes the debate in the USA about embryonic stem cells and how it polarized the nation. It covers many examples of political maneuvering to establish rules and regulations. It also has an international dimension and describes the legal position in countries around the world. I like it because I was in the USA during many of these debates and feel the book nicely captures the atmosphere of the controversy.
Today's scientists are showing us how stem cells create and repair the human body. Unlocking these secrets has become the new Holy Grail of biomedical research. But behind that search lies a sharp divide, one that has continued for years. Stem cells offer the hope of creating or repairing tissues lost to age, disease, and injury. Yet, because of this ability, stem cells also hold the potential to incite an international biological arms race.
The Stem Cell Dilemma illuminates everything you need to know about stem cells, and in this new edition the authors have included up-to-date information on scientific…
My son loves this book because of the pictures. They are funny and do a great job illustrating the story of life on Earth and how it evolved.
My son also wants me to mention that he appreciates the specific examples it gives as he feels it does an excellent job of teaching evolution (which is a very precocious thing to say). To his credit, he can explain evolution to me, which I don't think I could do at his age.
This wonderful book introduces children to the story of life and how it all began. Using bitesize text and beautifully bright illustrations this is the perfect book for budding scientists and those eager to learn more about our amazing planet.
Are you ready for an exciting and dramatic story about how life began and developed on Planet Earth? Packed full of fascinating facts and funny illustrations, this is the perfect introduction to life on earth for even the youngest of readers.
At first, nothing lived on Earth. It was a noisy, hot, scary place. Choking gas exploded from volcanoes and…
I spent my career in developmental biology: the science of how embryos develop. My main discovery was the discovery of one of the signals that controls development, called the fibroblast growth factor. Stem cell biology grew up on the basis of previous discoveries in developmental biology, and now, every day, people around the world use fibroblast growth factor among other substances to control the development of their stem cells. From 2007-2012 I was Director of the Stem Cell Institute at the University of Minnesota, so I got a good inside view of the whole field.
This book is much better than it looks at first sight. Although the “for dummies” theme might be off-putting to some, it is a serious account of stem cells with good scientific content. With 360 pages it has space to cover many topics and deals with the legal and ethical side of the field as well as the science and medicine. To me, it is perhaps a little too credulous about “miracle cells” that can turn into anything but is a lot less credulous than many other sources.
The first authoritative yet accessible guide to this controversial topic Stem Cell Research For Dummies offers a balanced, plain-English look at this politically charged topic, cutting away the hype and presenting the facts clearly for you, free from debate. It explains what stem cells are and what they do, the legalities of harvesting them and using them in research, the latest research findings from the U.S. and abroad, and the prospects for medical stem cell therapies in the short and long term. Explains the differences between adult stem cells and embryonic/umbilical cord stem cells Provides both sides of the political…
I spent my career in developmental biology: the science of how embryos develop. My main discovery was the discovery of one of the signals that controls development, called the fibroblast growth factor. Stem cell biology grew up on the basis of previous discoveries in developmental biology, and now, every day, people around the world use fibroblast growth factor among other substances to control the development of their stem cells. From 2007-2012 I was Director of the Stem Cell Institute at the University of Minnesota, so I got a good inside view of the whole field.
This is a beautiful book written by a great team from Utrecht in the Netherlands. It starts with a potted introduction to cell and developmental biology. I like this because, as a developmental biologist myself, I know that it is the basic science underpinning stem cell biology. It explains embryonic stem cells and cloning. Before covering transplantation therapy it explains about immune rejection of grafts and how this is dealt with. Unlike most books on stem cells, it covers non-therapeutic applications such as the study of human development or the use of stem cell-derived cells for safety testing of drugs.
The first and second editions had fabulous colour pictures all the way through. Sadly the 3rd edition has been downgraded to black and white.
Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field.
I am a scientist who has worked at the coal face of the debate around the origin of animals and ‘Snowball Earth’ his entire career, using a combination of experimental and descriptive science. Over three decades, I have witnessed first-hand how careful attention to detail in study after study has removed doubt from once provocative, even crazy, ideas that are now widely accepted. I love reading popular science from the perspective of the hands-on scientist who has witnessed the debate first-hand and contributed to received knowledge by conceiving new experiments, amassing data, and, more than often, in entirely unexpected ways through sheer curiosity.
I cherish this book as I can dip into any part of it and will always learn something new.
I have always been fascinated by the origin of things, and there is nothing more fundamental than the origin of life itself. Nick Lane is on the front line of such research and brings a lot to bear down on this question, from his own laboratory experiments to theoretical biochemistry, all without a hint of condescension. Nick wants to take the reader with him on a personal journey to discover why we are here, and this is a journey I wouldn’t miss for the world.
The Earth teems with life: in its oceans, forests, skies and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
For two and a half billion years, from the very origins of life, single-celled organisms such as bacteria evolved without changing their basic form. Then, on just one occasion in four billion…
I’ve long been fascinated by how life unfolds from a single fertilized egg cell containing just one set of DNA, whether it’s a human, mouse, frog, worm, or anything else. While studying for my PhD in the Gurdon Institute in Cambridge, which combines brings together researchers working on development and cancer, and spending twelve years in science communication at Cancer Research UK, the world’s largest cancer research charity, I came to see cancer and development as two sides of the same coin: one process unfolding healthy life as egg becomes embryo, and the other ultimately bringing disease and death as a single cell grows into a deadly tumor.
Written for a more academic audience than the other books on this list, although still highly readable, I’d recommend Adaptive Oncogenesis for anyone wanting to go deeper into the underlying evolutionary principles that explain why we get cancer when we do. James explores how the disease is fundamentally hardwired into our human biology, how the processes of evolution shape how cancer starts, grows, and spreads through the body, and new ideas for more effective approaches to treatment.
Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success.
Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment…
