Evolution is the most general theory of biology that we have. I seek to employ evolutionary principles to provide a predictive framework for both current ecological interactions and interactions that occurred earlier in the history of life. A generation ago, the study of cooperation was revolutionized by the deceptively simple notion of “follow the genes.” Embracing another simple notion—follow the electrons—can have an equally large effect in illuminating cooperation. Connecting evolutionary biology to biochemistry, however, remains a challenge—many evolutionary biologists dislike biochemistry and are much more comfortable with the informational aspects of life (e.g., genes). The below “best books on bioenergetics” can help to bridge this gap.
I wrote
Energy and Evolutionary Conflict: The Metabolic Roots of Cooperation
In the late-twentieth century, large scientific conflicts flared in two seemingly distinct fields of scientific inquiry. In bioenergetics, which examines how…
A comprehensive and very readable biography of oxygen, its scientific study, and its role in the history of life on Earth.
The “big picture” view is grounded in numerous anecdotes of individual scientists’ work. The relevant scientific history blends nicely with the history of life. Throughout, we see oxygen generated by oxygenic photosynthesis, consumed by oxidative phosphorylation, with leftovers drifting up into the atmosphere to eventually produce the planet that supports human civilization and much else besides.
Oxygen has had extraordinary effects on life. Three hundred million years ago, in Carboniferous times, dragonflies grew as big as seagulls, with wingspans of nearly a metre. Researchers claim they could have flown only if the air had contained more oxygen than today - probably as much as 35 per cent. Giant spiders, tree-ferns, marine rock formations and fossil charcoals all tell the same story. High oxygen levels may also explain the global firestorm that contributed to the demise of the dinosaurs after the asteroid impact. The strange and profound effects that oxygen has had on the evolution of life…
Oxygen is critical to life as we know it, yet for much of the history of life oxygen was scarce to non-existent, and this continues to be the case in some modern environments.
While anaerobiosis is only a minor inconvenience to many microorganisms, what about complex multicellular organisms such as animals (aka metazoans)? Beginning with aspects of the physical chemistry of oxygen, this volume fills in the fairly stereotypical ways that animals cope with oxygen limitation, both temporally and spatially.
Notably, many animals have a much more sophisticated anaerobic metabolism than human beings.
Many multicellular animals do not require oxygen to live but respire anaerobically. Some of these have adapted to "hostile" environments, such as sulphide rich habitats, others live as parasites within host organisms, while others still can perhaps be said to look back on the early days of life on earth before anaerobic respiration had evolved. This comprehensive volume lays out detailed summaries of the strategies for anero- or anoxy-biosis employed by each major group of metazoan animals. It begins with a description of the physical chemistry of oxygen, followed by a dissertation on the perils - and opportunities - created…
So, how is oxygen involved in bioenergetics? Perhaps remarkably, the modern view of bioenergetics only recently emerged in the closing decades of the 20th century.
As related in this volume, the chemiosmotic hypothesis of Peter Mitchell roiled the field of bioenergetics and led to the nearly two-decade “oxphos wars.” In the end, the chemiosmotic hypothesis was triumphant, and bioenergetics became the study of building and harnessing trans-membrane ion gradients.
In this context, oxygen takes its place as a terminal electron acceptor, which by facilitating electron flow through the electron transport chain, helps to build the trans-membrane proton gradient. There are, of course, quite a few other actual or potential terminal electron acceptors, and there is much more in this volume about how organisms move electrons around to convert energy.
Lest we forget, however, oxygen was “missing in action” for most of the history of life and can be scarce in some habitats even today. Hence, even complex eukaryotes, which might usually depend on oxygen as a terminal electron acceptor, must have a “plan B.”
Building on the earlier work by Bryant (1991) and others, this volume outlines in considerable detail how eukaryotes manage their energetics without oxygen. Some of these mechanisms involve building trans-membrane proton gradients in mitochondria anaerobically. This is not something that human cells can do. Rather, our cells rely on lactate formation when anaerobic.
Indeed, some human cancers exhibit the so-called Warburg effect—aerobic glycolysis, diminished oxygen consumption, and lactate secretion. What would this effect look like in some of these organisms that use mitochondria anaerobically?
Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not…
Study of the Warburg effect has stimulated broader interest in how metabolism might regulate cellular and organismal biology.
This volume gives voice to this nascent field. The Krebs or tricarboxylic acid cycle—the “one ring to rule them all”—produces reduced co-enzymes that are then oxidized by the electron transport chain to produce the trans-membrane proton gradient. The Krebs cycle also produces numerous precursors for biosynthesis. It can thus signal the metabolic state of the cell, switching numerous genes on or off.
Intermediary metabolism, long ignored by many biologists, may thus be the key to much of what cells and organisms are and what they do.
What brings the Earth to life, and our own lives to an end?
For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight -how the same simple chemistry gives rise to life and causes our demise.
Lane is among the vanguard of researchers asking why the Krebs cycle,…
In the late-twentieth century, large scientific conflicts flared in two seemingly distinct fields of scientific inquiry. In bioenergetics, which examines how organisms obtain and utilize energy, the chemiosmotic hypothesis of Mitchell suggested a novel mechanism for energy conversion. In evolutionary biology, meanwhile, Wynne Edwards strongly articulated the view that organisms may act for the “good of the group,” thus crystallizing a long history of imprecise thinking on the evolution of cooperation. Perhaps surprisingly, the former may illuminate the latter. Chemiosmosis rapidly converts energy, and once storage capacity is exceeded, an overabundance of products has various negative consequences. While chemiosmotic processes can be modulated, under certain circumstances it is also possible to simply disperse the products into the environment. Sharing and cooperation may thus be favored.
I come by my interest in history and the years before, during, and after the Second World War honestly. For one thing, both my father and my father-in-law served as pilots in the war, my father a P-38 pilot in North Africa and my father-in-law a B-17 bomber pilot in England. Their histories connect me with a period I think we can still almost reach with our fingertips and one that has had a momentous impact on our lives today. I have taken that interest and passion to discover and write true life stories of the war—focusing on the untold and unheard stories often of the “Average Joe.”
October 24, 1944, is not a day of national remembrance. Yet, more Americans serving in World War II perished on that day than on any other single day of the war.
The narrative of No Average Day proceeds hour by hour and incident by incident while focusing its attention on ordinary individuals—clerks, radio operators, cooks, sailors, machinist mates, riflemen, and pilots and their air crews. All were men who chose to serve their country and soon found themselves in a terrifying and otherworldly place.
No Average Day reveals the vastness of the war as it reaches past the beaches in…
October 24, 1944, is not a day of national remembrance. Yet, more Americans serving in World War II perished on that day than on December 7, 1941, when the Japanese attacked Pearl Harbor, or on June 6, 1944, when the Allies stormed the beaches of Normandy, or on any other single day of the war. In its telling of the events of October 24, No Average Day proceeds hour by hour and incident by incident. The book begins with Army Private First-Class Paul Miller's pre-dawn demise in the Sendai #6B Japanese prisoner of war camp. It concludes with the death…
