100 books like Transformer

Once upon a time, we were unaware of DNA. We could tell that taller parents have taller kids, we could select tomato plants for sweeter fruit, and we could even construct plausible relationships between long-extinct animals and their descendants. Still, the nature of the stuff from which these links are made and how it works or fails to work remained a mystery.

Solving this mystery is one of humanity’s most remarkable achievements, and Mukherjee tells the tale with style and humor, weaving in recollections of his family’s encounters with mental illness. Despite my familiarity with the end result, the modern picture of genes, I found much of the history surprising and surprisingly colorful, full of dead ends and creative leaps. The last third of the book, on complex traits like intelligence and illnesses like schizophrenia, isn’t quite as good as the rest, but that takes us to our second… show more.

This isn’t a book about biology, but it makes the list anyway. Genes, chemistry, and mechanics stretch our conception of life. Still, there’s more needed to make sense of it all: the emerging understanding that dynamic interactions, feedback loops, and a bit of randomness make life alive. We need more books that lay this out; this was one of my motivations for writing my book.

Philip Ball’s very recent How Life Works seems masterful, and I’m sure it would make this list if I were writing a month or two later, after I’ve finished reading it. But since I can’t list either my book or his, I’ll list Gleick’s book, one of the best popular science books ever. It dives into the science of order and chaos, from the turbulence of Jupiter’s red spot to the unpredictability of weather, with a bit of biological pattern formation in the mix.… show more.

What does DNA have to do with education, social justice, income inequality, and other weighty topics? I’ve never read anything that makes such a compelling case that the modern revolution in genetics should impact how we structure society as much as it impacts how we treat disease. First, Harden presents wonderful, accessible descriptions of the current state of genetics, including how we know what we know. Genes have a huge impact on life outcomes.

Harden firmly believes that it would be a mistake to sweep genetic research under the rug for misguided but well-meaning reasons; this seems obvious, but it is radical in current social science. Harden explains that taking genetics seriously has surprising consequences for what we consider a fair society; we shouldn’t mistake being genetically lucky for being good.

The book is controversial, and I certainly found myself disagreeing with some of Harden’s conclusions while at the same… show more.

A comprehensive and very readable biography of oxygen, its scientific study, and its role in the history of life on Earth. 

The “big picture” view is grounded in numerous anecdotes of individual scientists’ work. The relevant scientific history blends nicely with the history of life. Throughout, we see oxygen generated by oxygenic photosynthesis, consumed by oxidative phosphorylation, with leftovers drifting up into the atmosphere to eventually produce the planet that supports human civilization and much else besides.

Oxygen is critical to life as we know it, yet for much of the history of life oxygen was scarce to non-existent, and this continues to be the case in some modern environments. 

While anaerobiosis is only a minor inconvenience to many microorganisms, what about complex multicellular organisms such as animals (aka metazoans)? Beginning with aspects of the physical chemistry of oxygen, this volume fills in the fairly stereotypical ways that animals cope with oxygen limitation, both temporally and spatially. 

Notably, many animals have a much more sophisticated anaerobic metabolism than human beings.

So, how is oxygen involved in bioenergetics? Perhaps remarkably, the modern view of bioenergetics only recently emerged in the closing decades of the 20th century. 

As related in this volume, the chemiosmotic hypothesis of Peter Mitchell roiled the field of bioenergetics and led to the nearly two-decade “oxphos wars.” In the end, the chemiosmotic hypothesis was triumphant, and bioenergetics became the study of building and harnessing trans-membrane ion gradients. 

In this context, oxygen takes its place as a terminal electron acceptor, which by facilitating electron flow through the electron transport chain, helps to build the trans-membrane proton gradient. There are, of course, quite a few other actual or potential terminal electron acceptors, and there is much more in this volume about how organisms move electrons around to convert energy.

Lest we forget, however, oxygen was “missing in action” for most of the history of life and can be scarce in some habitats even today. Hence, even complex eukaryotes, which might usually depend on oxygen as a terminal electron acceptor, must have a “plan B.” 

Building on the earlier work by Bryant (1991) and others, this volume outlines in considerable detail how eukaryotes manage their energetics without oxygen. Some of these mechanisms involve building trans-membrane proton gradients in mitochondria anaerobically. This is not something that human cells can do.  Rather, our cells rely on lactate formation when anaerobic. 

Indeed, some human cancers exhibit the so-called Warburg effect—aerobic glycolysis, diminished oxygen consumption, and lactate secretion. What would this effect look like in some of these organisms that use mitochondria anaerobically?

I started out as a fairly standard physicist, working with magnets, nanocrystals, and other inert “stuff.” I ended up a biophysicist, studying living things through a physical lens. A bit like Dorothy in Oz, I found myself in a world with amazing vibrancy and variety but still with many echoes of familiar past experiences.

There wasn’t a single tornado that took me to the Oz of biophysics but several, one of which was this book. Vogel describes the challenges of living in the physical world and nature’s ingenious schemes for meeting these challenges. We learn how prairie dogs keep from suffocating in their burrows, the speed limit of ducks, and how trees struggle with air bubbles.

Vogel’s writing is warm and folksy, and though this book is the only book on this list with many equations, the style makes it a delight even for the reader who might like to… show more.

My husband has a PhD in chemistry, and this book is a fabulous way for him to begin introducing some chemistry and STEM terms to our son. It’s written in a simple way that is easy for a young child to follow.

Even if you’re not a chemist, it’s still a great book to share with your kids. And you might learn something, too! (I did!)

We’ve outgrown vaulting over five-barred gates, running up mountains, drinking all night, and springing bright-eyed from our beds, and so what? For anyone in denial, or clinging stubbornly to youth, Dave is the Baby Boomer to point out the stark realities. He’s funny but he’s ruthless. Fifty’s not the new thirty. It’s fifty. The reason I recommend it is that it can be hard to let go and you’ll waste precious autumn if you don’t accept the inevitable, and move on with a spring in your step into what I have found to be the best period of all. Laughing helps. Laughing always helps.