100 books like The Right Price

This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.

Legislators and healthcare insurers are seeking ways to slash healthcare costs, often focusing on cutting the costs of medicines through schemes like price controls. Yet, drugs make up only about 13 percent of the money paid on healthcare. This book does a great job of explaining what is behind the pricing of new drugs but, more importantly,  shows that all life-saving drugs eventually become low-cost generics – truly a Great American Drug Deal.

This book scrutinizes all players in the healthcare industry and offers new ideas for cost-saving measures, such as closing loopholes, dealing with bad actors, and educating consumers. If you want to understand how best to balance innovation and affordability, this book is a must-read. 

There’s a seedy side to the pharmaceutical industry that started well before the creation of the FDA, and continues through the modern era, fueling the epidemic of opioid drug dependency.

In Pharma, Posner’s comprehensive reporting introduces us to brilliant scientists, incorruptible government regulators, and brave whistleblowers facing off against company executives often blinded by greed.

We learn how the Sacklers built a culture of pain relief on the shoulders of oxycontin – one that ultimately led to the lowest survival rates for Americans in a century.

I found, as a history buff, The Struggle for Drug Reform to be an eye-opener about how America’s exceptionally high drug prices among other deficits in health care quality and coverage resulted from the past exercise of power by the pharmaceutical industry, the lynchpin of America’s “medico-industrial complex.”

I was impressed by historian Tobbell’s meticulously researched account of the industry’s strategic alliances with self-interested medical scientists, not just conservative political forces, and its use of anti-communist propaganda to fight off the threat of drug pricing regulations.

I personally found important her discussions of how the industry allied with the American Medical Association against universal health care, against FDA demands for evidence about drug efficacy and safety before allowing drugs on the market, and against the threat to its profits from generic drugs. 

One of my all-time favourites I’ve read this book 3 times now and, after this review, I’m sure I’ll be tempted to indulge myself for a fourth time. Follett is the master of knife-edge thrillers, if you’ve never read him, start now. Full of treachery and violence, twists and revelations. It’s a scary, but utterly brilliant read.

If you think that medical journals published by respected medical societies are full of good science, think again.

For me, Abramson’s Sickening nailed the case for a conclusion that the net effect of the many hundreds of medical journals published here and around the world is to subtract from the sum of human medical knowledge.

Abramson, as an expert witness in criminal and civil cases against drug companies, draws in part on subpoenaed documents to expose how medical science, as part of the entire medical-industrial complex, is corrupted from start to finish by the drug industry’s funding of most clinical trials, their control over the data analysis, and even their ghost-writing of articles submitted to journals.

New and disturbing was the withholding of clinical trials’ raw data from journals’ peer reviewers. Instead, they get biased summaries bearing drug manufacturers’ fingerprints.

I find Angell’s The Truth About the Drug Companies extremely valuable for teaching students about how the pharmaceutical industry translates high profits into power resources to protect and increase those profits over time.

The former New England Journal of Medicine editor exposed how drug companies enlist politicians, the FDA, and medical academia for their cause. And armies of lawyers to extend monopoly marketing rights for years.

It was my first introduction to how they spend more on marketing than research, much of that on “copy-cat” drugs of dubious superiority to ones with expired patents.

As a tax (and high drug price) payer, I was disturbed to learn how they use government funds for basic research and then rig and spin their reporting of clinical studies to inflate their products’ therapeutic value and underplay their risks. 

A clever introduction to Victorian pharmaceuticals and remedies, this is a companion book for the popular BBC television series. It provides an explanation of the natural substances used for healing, and how they were made into marketable and regulated medicines for sale at the apothecary shop. The emphasis is on safety, because the authors don’t want you trying arsenic and mercury-based compounds at home, and indeed they leave out a great many useful Victorian remedies, particularly those containing opium! But the knowledge about how apothecary shops worked, and what the pharmacist did to turn plants and other substances into medicine, is invaluable.

One of the main characters of this novel is a horse whisperer whose traumatic experiences on his eighth birthday have left him unable to speak. When he hears about stallions who are kept entirely indoors in order to produce a new drug, he sets out to ease their suffering. In the process, he meets Karen Lawford, the workaholic heir to the drug company, and tries to reawaken her love for horses so she can see that what is happening to the stallions is wrong, and tries to help her too. I love this well-crafted story of love and healing, but feel I should mention that it includes horses dying and being badly treated.