86 books like I Contain Multitudes

I love this book because it turns the most impactful science discovery of the 21st century–CRISPR gene editing–into a page-turner. Isaacson combines a biography of Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier, with lucid accounts of the science and sequence of research breakthroughs that underlie CRISPR editing, as well as the intrigues and jockeying among powerful scientists and personalities vying for prizes and patents on the technology.

I came through this book to appreciate the enormous potential of CRISPR gene editing for good (curing hereditary diseases) and not-so-good (designer babies or, in the words of Vladimir Putin, “a soldier, an individual who can fight without fear or compassion, mercy or pain”). CRISPR promises to make human selection as important as natural selection in the evolution of many species, including humans.

Is it nature or nurture that makes a person? Well, it depends on the trait. Many things (e.g., number of noses or biological sex) are genetically determined. Other traits like IQ are about 50/50 genes and environment. Still others, like language, are entirely environmental. 

Humans are fascinated by genetic determinism and its contributions to race, gender, feeble-mindedness, disease. Witness the popularity of 23 and Me. Zimmer’s wonderful book gives an even-handed and sometimes brave account of the history of our obsession with heredity and some of the terrible things that have emerged from it: eugenics, forced sterilization, concern about human "mongrels," the concept of racial purity.

I was fascinated by the details he dug up, explaining the life experiences of individual people who fell afoul of government programs to "improve" the human population. 

Sally Smith Hughes' highly readable tale of the genesis of Genentech provides a no-holds-barred look into the gritty details of how biotech firms are born. Hughes reveals how scientists, lawyers, and venture capitalists work together and collide in a crucible of competing disciplines and desires to produce transformative advances. For those interesting in biotech entrepreneurship or simply investing in biotech, this book offers key foundational insights into the industry.

John Rhodes, author of The End of Plagues: The Global Battle Against Infectious Disease now offers us a timely, concise, and easy-to-digest book that spans the history of vaccines, including the recent development of mRNA vaccines now on the frontlines of efforts to quell the COVID-19 global pandemic. Rhodes' experience and expertise in immunology and vaccine development show in his clear and easy-to-understand explanations of how vaccines work and why they are an essential public health tool.

As a microbial ecologist, I didn’t need to be convinced that microbes make all life on Earth possible. I knew that Falkowski, a preeminent biological oceanographer, would be a trustworthy guide in the microbial world. What makes this book so much fun to read is how Falkowski mixes science with snippets of history, both his own and of early scientists.  

Yet, the science is the main story here and is fascinating. Microbes, specifically cyanobacteria, are the engines that first put oxygen in the atmosphere around 2.4 billion years ago, which set the stage for the evolution of more complicated lifeforms, including, eventually, Homo sapiens.  Microbes are also the ancestral source of what Falkowski calls nanomachines, which continue to power all organisms today. Falkowski convincingly argues that microbes are what make life on Earth possible. 

There are novels based on this book, which are also enthralling. Having been an academic all my life, I was immediately captured by Simard’s daring struggle to tell the truth that goes against the established scientific order. She took me on her own adventure to understand the sociality of trees. I read it during the COVID pandemic when pretty much the only beings I related to were trees in my nearby Botanic Garden.

There was an oak tree I talked to every day, and lying in its shelter, I was protected by it. Later, I came to love an Angophora costata, who loved me right back. Simard gave me insights into the possibility of such relationality and its vital importance to the world’s future.

How can you not love a book that argues that, despite being mostly microbial, “the plankton form the bulk of the living fabric of the ocean, the web of life that is an integral part of the blue machine.”

Czerski’s prose is as vivid as describing other, larger parts of the blue machine, such as Greenland sharks, which live for hundreds of years, and whales whose earwax records the stress caused by global warming. Equally entertaining and captivating are her accounts of canoeing off Maui, fieldwork in the Arctic, and everyday life on an oceanographic ship.

Although the writing is always light and the metaphors evocative, Czerski makes several serious points about the ocean and climate change. If not for the ocean, atmospheric levels of the most important greenhouse gas, carbon dioxide, would be even higher and global warming worse.

I almost put this book down when Marra started to describe what happened one early morning off the coast of Iceland, where he was trying to measure photosynthesis by marine microbes. A day earlier, he had filled bottles with seawater spiked with a radioactive form of carbon, carbon-14, and thrown the bottles overboard to incubate in the ocean. Now he had to retrieve them. As Marra recounted how the ship rolled in huge waves whipped up by 55-knot winds, my stomach churned as I remembered similar experiences on other vessels, in other seas.

Luckily for me and perhaps other seasick-prone readers, Hot Carbon returns to land for several chapters to sketch out the discovery of carbon-14 and its use in C14-dating historical artifacts such as the Shroud of Turin and in unraveling the mechanism of photosynthesis.

In the last part of the book, Marra returns to the ocean and outlines… show more.

Inside Your Insides does a nice job of taking a journey through the body and exploring which microbes live at the stops along the way.

After a brief intro into the microbiome and a distinction between helpful (“Some Of Your Microbes Are Good Guys”) and harmful (“Some of Your  Microbes Are Bad Guys”) little fellas, the book focuses on different areas of the body: skin, mouth, lungs, gut… and dives into information and anecdotes about the microbes that call that region home.

Playful germ-jokes and fun-facts dance along the edges of the pages and the book closes out with tips to treat your microbiome with care.  

In Life on Man, the brilliant bacteriologist and renowned professor Theodor Rosebury became the first to introduce the public to the world of bacteria within and around them. He did so with irreverence and humor that shocked and delighted without sacrificing scientific accuracy and prudence. Though our understanding of the bacterial world has progressed light years since Life on Man was first published in 1969, it remains a classic. A must-read for everyone seriously interested in our personal microbiomes.