5 books like Madness and Memory

Perhaps one of the greatest books ever written. Kuhn is one of the most brilliant thinkers in human history, the creator of the word “paradigm.” This book examines how science progresses over time, one worldview replacing another. More significantly, Kuhn argued that defenders of the current paradigm resist any challenge to its tenets to maintain respect and privilege. In short, science is limited by human insecurity and ego. I found this book to be imperative to any understanding of how the world works. 

This book explains the tight connection between Alzheimer’s disease and education, health, income, and environment, and why the rate of Alzheimer’s disease in the population actually decreased in the decades following the most important societal changes enacted after World War II. Social safety, environmental protections, and income inequality have had far greater impact than any of the pharmacological approaches ever attempted. The authors make the compelling case that brain health is intimately connected to societal health.

This book offers a captivating tale of how the increasing knowledge of one disease, syphilis, created the foundations to understanding that the brain and mind are one and the same. The authors narrate the stories of patients whose “hysteria” (today referred to as functional neurological disorder) were traced to degenerative brain lesions that only belatedly were understood to be complications caused by remote infections with the bacterium Treponema pallidum. Several chapters follow the story of the important characters depicted by André Brouillet in the Une leçon clinique à la Salpêtrière (A Clinical Lesson at the Salpêtrière), one of the most recognized paintings by neurologists, as it depicts Jean-Martin Charcot, shown among many of his disciples, demonstrating a “hysteric” seizure in one of his patients. The authors illustrate how we have gotten away with conceptualizing behaviors without biological basis and put the reader on notice that “mental illnesses” are neurological problems… show more.

This collection of essays blew my mind. Researchers in a range of disciplines were asked to elaborate on why a given idea in their field should be put to rest. There is a chapter dedicated to big data, nature versus nurture, cause and effect, race, Linnaean classification, etc. The book’s essays inspired me to shape a section on “Reductionism and related ideas that will die” as part of a solicited article I wrote with Tony Lang in 2018 aiming to predict the future of Parkinson’s disease research in the 2020s (Ben Stecher credited it as his reason to relocate to Cincinnati to work with us in our CCBP study). This book is also a reminder that progress requires new ideas, and most cannot emerge without first abandoning outdated ones (as Kuhn articulated).  

An idea that must die in neurology is the clinico-pathologic model of classifying neurodegenerative diseases: abnormalities on brain… show more.

Gerritsen’s Life Support is a suspense-filled cliffhanger that makes use of spongiform encephalitis, a brain disease caused by prions. Remember Mad Cow Disease? It’s a type of problem that stretches the meaning of “infection.” The story is based on the fictional use of fetal pituitary cells from aborted fetuses to return youthful strength and vigor to elderly rich people. The group making millions from this obtains fetuses from a Mexican village where the cows are dying. A year later, several of their patients die of Creutzfeldt-Jakob disease, an extremely rare human type of spongiform encephalitis. Corpses accumulate and suspense builds during the coverup.