The best thrillers with the most unique premises

Why am I passionate about this?

I love thriller stories. I also love a variety of types of thrillers because there are so many ways for someone to face great challenges, overcome those hurdles, and achieve a major goal, all in the context of high stakes and fast-paced situations. It doesn’t matter if the story is related to crime, medicine, science, law, politics, espionage, etc. After experiencing such a diversity of thriller stories, including the books recommended below, I am passionate about creating my own stories, based on my life experiences and endless imagination.


I wrote...

Doctor Lucifer

By Anthony Lee,

Book cover of Doctor Lucifer

What is my book about?

In this medical thriller about healthcare and cybersecurity, a computer hacker named Doctor Lucifer harms and kills a doctor’s patients just by digitally altering medical records.

Dr. Mark Lin, an intelligent but cynical hospital internist, faces blame for three medication errors caused by Doctor Lucifer and knows his reputation is on the line. With the help of two information technology specialists, Mark scrambles to avert one medical crisis after another and outsmart Doctor Lucifer, all while facing a vengeful widow and an egotistical surgeon. Soon, Mark hits rock bottom and has no choice but to hunt down Doctor Lucifer, an enemy with a truly malicious purpose.

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The books I picked & why

Book cover of Gravity

Anthony Lee Why did I love this book?

Many medical thrillers are set in a hospital or similar setting, but this one is, I believe, the only one set on the International Space Station.

I found it so scary to experience one catastrophe after another in a place where access to help is so far away. I also loved the unique combination of medical science and space science, something that is rarely seen in thriller fiction.

By Tess Gerritsen,

Why should I read it?

2 authors picked Gravity as one of their favorite books, and they share why you should read it.

What is this book about?

Top Ten bestselling author Tess Gerritsen delivers a thoroughly menacing new thriller. A brilliantly compulsive page-turner from the author of The Surgeon.

Dr Emma Watson, a brilliant research physician, has been training for the mission of a lifetime: to study living organisms in space. Jack McCallum, Emma's estranged husband, has shared her dream of space travel, but a medical condition has grounded him. Now he must watch from the sidelines...

The mission aboard the space station turns into a nightmare when a culture of single-celled organisms begins to regenerate out of control - and infects the crew with agonising and…


Book cover of Fair Warning

Anthony Lee Why did I love this book?

I love Michael Connelly’s crime thrillers featuring Harry Bosch and legal thrillers centering on Mickey Haller, but let’s not forget his thrillers focusing on journalist Jack McEvoy, especially this third one.

What gripped me so much while reading this story is how the villain knows more about the protagonist than the other way around, along with the horrifying consequences of genetic information getting into the wrong hands. Combine that with not knowing yet who the villain is, and you have a thriller that is no doubt heart-pounding.

By Michael Connelly,

Why should I read it?

1 author picked Fair Warning as one of their favorite books, and they share why you should read it.

What is this book about?

HOW DO YOU FIND A KILLER WHO KNOWS EVERYTHING ABOUT YOU?

'AS EXCITING AS ANYTHING CONNELLY HAS WRITTEN' THE TIMES

* * * * *

Jack McEvoy is a reporter with a track record in finding killers. But he's never been accused of being one himself.

Jack went on one date with Tina Portrero. The next thing he knows, the police are at his house telling Jack he's a suspect in her murder.

Maybe it's because he doesn't like being accused of a crime he didn't commit. Or maybe it's because the method of her murder is so chilling that…


Book cover of From Russia with Love: A James Bond Novel

Anthony Lee Why did I love this book?

Fictional British secret agent James Bond may be well known from a decades-old film series, but he ultimately originated in a series of spy thrillers by Ian Fleming.

Of all 14 Bond books by Fleming, this book is no doubt his best one. The type of scheme that the villains have arranged for Bond is startling, and what is just as shocking is the moment when it is all revealed to the main character.

This book is so good that John F. Kennedy actually listed it as one of his favorite books while he was the President of the United States.

By Ian Fleming,

Why should I read it?

3 authors picked From Russia with Love as one of their favorite books, and they share why you should read it.

What is this book about?

JAMES BOND GOES HEAD-TO-HEAD WITH SMERSH IN A BID TO SECURE A KEY PIECE OF SOVIET INTELLIGENCE

SMERSH, the Russian intelligence unit whose acronym stands for “Death to Spies,” is hell-bent on destroying Special Agent James Bond.

His death would deal a catastrophic hammer blow to the heart of the British Secret Service.

The lure? A beautiful woman who needs 007’s help. Tatiana Romanova is a Russian spy who promises to hand over the prized Spektor decoding machine if Bond aids her defection. Bond suspects a trap but can’t resist the opportunity to give the British the upper hand in…


Book cover of Isolation Ward: A Novel of Medical Suspense

Anthony Lee Why did I love this book?

The plot premise of an infectious disease outbreak is all too common among medical thrillers, but when you have a young investigator from the Centers for Disease Control looking into it and uncovering a shocking scheme, the result is a thrilling detective novel that is oriented in medicine, not just a medical thriller.

I especially loved how the text incorporates a hardboiled narrative tone in the spirit of Raymond Chandler and Dashiell Hammett, something that is characteristic of crime fiction but not medical fiction.

By Joshua Spanogle,

Why should I read it?

1 author picked Isolation Ward as one of their favorite books, and they share why you should read it.

What is this book about?

Straight out of today’s hospitals and labs–and tomorrow’s headlines–comes a frightening, scalpel-sharp thriller from medical insider Joshua Spanogle. In an astounding debut, Spanogle takes us on an all-too-real race against time…as a young doctor enters the dark side of scientific research, desperate to stop a terrifying epidemic before it is too late….

In Baltimore’s St. Raphael’s Hospital, three newly admitted patients are among society’s most helpless citizens: female residents of Baltimore’s group homes for the mentally impaired, their bodies racked by a virus the likes of which no one at St. Raphael’s has ever seen.

Dr. Nathaniel McCormick is one…


You might also like...

The Blue Prussian

By Eve Penrose,

Book cover of The Blue Prussian

Eve Penrose

New book alert!

What is my book about?

The Blue Prussian is a spellbinding story told by Blake O’Brien, a beautiful, young executive with a globetrotting career. Blake returns to her native Manhattan from San Francisco after escaping—or so she thinks—her marriage to a dashing man who turned out to be a prince of darkness. She had been hoping for a fresh start but learns that she has been poisoned with thallium—a deadly neurotoxin referred to as the poisoner’s poison.

Blake is treated with the only known antidote—Prussian blue—the same synthetic pigment with the deeply saturated hue used in dazzling masterpieces like The Starry Night and The Great Wave. Almost unfathomably, the alchemist who invented Prussian blue was the rumored inspiration for Mary Shelley’s character, Dr. Frankenstein. The similarities to Blake’s financier ex are striking as his true nature is revealed—including the discovery of a secret room in the brooding Victorian home where they lived their married life together.

The stylish enclaves of Beekman Place in New York City, Nob Hill in San Francisco, and the Mayfair neighborhood in London provide the backdrop as this chilling tale of treachery and betrayal unfolds. Blake’s resolve triumphs, and the camaraderie of her loyal and charismatic friends fortifies her as she takes the reader on a tantalizing international pursuit to try to catch her poisoner, who is known to the FBI as The Blue Prussian.

The Blue Prussian

By Eve Penrose,

What is this book about?

"A modern-day Gaslight"

The Blue Prussian is a spellbinding story told by Blake O'Brien, a beautiful, young executive with a globetrotting career. Blake returns to her native Manhattan from San Francisco after escaping—or so she thinks—her marriage to a dashing man who turned out to be a prince of darkness. She had been hoping for a fresh start but learns that she has been poisoned with thallium—a deadly neurotoxin referred to as the poisoner's poison.

Blake is treated with the only known antidote—Prussian blue—the same synthetic pigment with the deeply saturated hue used in dazzling masterpieces like The Starry Night…


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