Here are 12 books that Understanding the Control of Metabolism fans have personally recommended if you like
Understanding the Control of Metabolism.
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Mathematics and chemistry were my strongest subjects at school, and I started programming computers when I was 16, but life seemed most important. Hence I studied biochemistry in university but moved into molecular biology with programming to assist the data analysis. My track record in successfully predicting new biology through computing led to a pharmaceutical company recruiting me to do bioinformatics for them. However, not content with studying genes and proteins, I pushed for bioinformatics to move up into metabolism, anatomy, and physiology. That’s when I discovered systems biology. My international reputation lies at this interface and includes discoveries in microbial physiology, botany, agriculture, animal biology, and antenatal diseases.
This book vindicates my long-held view that biological objects do not act in isolation but interact with other things to make a living whole. It confirms my opinion that genes are not the master controllers of living things.
Furthermore, it showed me that systems occur at different physical scales (molecules, cells, organs, organisms, populations), that the systems at these scales influence each other, and that no scale is dominant. To understand biological/medical phenomena, including human consciousness, one must look at the (multi-scale) systems, not their individual components, in isolation.
Finally, I found it a lot of fun to read because it uses hypothetical stories to illustrate points. For example, silicon-based aliens visit Earth but fail to understand why certain things and people behave the way that they do.
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes.
But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is…
Mathematics and chemistry were my strongest subjects at school, and I started programming computers when I was 16, but life seemed most important. Hence I studied biochemistry in university but moved into molecular biology with programming to assist the data analysis. My track record in successfully predicting new biology through computing led to a pharmaceutical company recruiting me to do bioinformatics for them. However, not content with studying genes and proteins, I pushed for bioinformatics to move up into metabolism, anatomy, and physiology. That’s when I discovered systems biology. My international reputation lies at this interface and includes discoveries in microbial physiology, botany, agriculture, animal biology, and antenatal diseases.
Of the various books available on this subject, I very much prefer this one because it makes it far easier to do systems biology.
First, it shows you how to view biological regulatory processes as a set of interacting components and their effect on each other. This alone can give clues to the behaviour of the system under different circumstances. However, it then goes on to show how these processes can be defined mathematically, which then enables us to get a quantitative view of what is going on.
When the predicted and observed numbers don’t match, we know that there is a gap in our knowledge and, hence, the place to discover new biology. Using this approach, I have.
... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. - Nature
[This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final…
Mathematics and chemistry were my strongest subjects at school, and I started programming computers when I was 16, but life seemed most important. Hence I studied biochemistry in university but moved into molecular biology with programming to assist the data analysis. My track record in successfully predicting new biology through computing led to a pharmaceutical company recruiting me to do bioinformatics for them. However, not content with studying genes and proteins, I pushed for bioinformatics to move up into metabolism, anatomy, and physiology. That’s when I discovered systems biology. My international reputation lies at this interface and includes discoveries in microbial physiology, botany, agriculture, animal biology, and antenatal diseases.
This is one of my most valued reference books, and I have referred to it many times.
With some explanatory text, it consists of a set of maps of biochemical pathways, differentiating between organism kingdoms, and includes how specific metabolites regulate the activity of particular enzymes. The pathways are very easy to find and easy to interpret. In contrast, the online equivalents can be difficult to interpret for a variety of reasons.
The book has the added advantage that it does not need a power supply or an internet connection and can be used in a far wider range of temperatures than computer hardware.
The pathways and networks underlying biological function
Now in its second edition, Biochemical Pathways continues to garner praise from students, instructors, and researchers for its clear, full-color illustrations of the pathways and networks that determine biological function.
Biochemical Pathways examines the biochemistry of bacteria, plants, and animals. It offers a quick overview of the metabolic sequences in biochemical pathways, the chemistry and enzymology of conversions, the regulation of turnover, the expression of genes, the immunological interactions, and the metabolic background of health disorders. A standard set of conventions is used in all illustrations, enabling readers to easily gather information and…
Everybody knows that all animals—bats, bears, sharks, ponies, and people—start out as a single cell: the fertilized egg. But how does something no bigger than the period at the end of this sentence give rise to the remarkable complexity of each of these creatures?
Mathematics and chemistry were my strongest subjects at school, and I started programming computers when I was 16, but life seemed most important. Hence I studied biochemistry in university but moved into molecular biology with programming to assist the data analysis. My track record in successfully predicting new biology through computing led to a pharmaceutical company recruiting me to do bioinformatics for them. However, not content with studying genes and proteins, I pushed for bioinformatics to move up into metabolism, anatomy, and physiology. That’s when I discovered systems biology. My international reputation lies at this interface and includes discoveries in microbial physiology, botany, agriculture, animal biology, and antenatal diseases.
This book has been a companion for almost three decades.
Any bona fide bioinformatician will write some program scripts if only to reformat data in new and useful ways. Perl is not the most efficient or widespread scripting language, but it has the advantage of being highly flexible. It offers many ways to write a program to carry out a given task, so even computationally naive programmers can generate effective code.
Even though I am no longer actively developing software, I still have occasions when it is quicker to script something in Perl than do battle with larger apps.
When it comes to learning Perl, programmers consider this book to be the undisputed bible. You not only learn every nuance of this language, you also get a unique perspective on the evolution of Perl and its future direction. The 4th edition has been thoroughly updated for version 5.14, with details on regular expressions, support for UNICODE, threads, and many other features. Many Perl books explain typeglobs, pseudohashes, and closures, but only this one shows the motivations behind these features and why they work the way they do. It's exactly what you'd expect from its prominent authors: Larry Wall is…
I went on my first diet in high school, a reaction to panic brought on by weight gain (which was a completely normal part of puberty). That first diet led to a decade of yo-yo dieting and food and body obession. It also led me to pursue a career in nutrition and fitness. Six years ago, I came across the book Intuitive Eating, which completely changed my life. Now, as a registered dietitian, nutrition therapist, and certified intuitive eating counselor, I'm passionate about helping people reclaim the space to eat and live, unapologetically. I'm the founder of Alissa Rumsey Nutrition and Wellness, a weight-inclusive nutrition practice that offers virtual counseling, group programs, and online trainings.
Body Respect was one of the first books that introduced me to the Health at Every Size® approach which changed how I thought about health. The book highlights the science behind health and weight in an approachable and easy-to-understand way. They break down the reasons why weight loss is not the key to health, the misconceptions of the BMI, and why fatness is not as linked to health as we’ve been led to believe.
Mainstream health science has let you down. Weight loss is not the key to health, diet and exercise are not effective weight-loss strategies and fatness is not a death sentence. You've heard it before: there's a global health crisis, and, unless we make some changes, we're in trouble. That much is true--but the epidemic is NOT obesity. The real crisis lies in the toxic stigma placed on certain bodies and the impact of living with inequality--not the numbers on a scale. In a mad dash to shrink our bodies, many of us get so caught up in searching for the…
Since childhood, I’ve wanted to find out how things work. The human body is an amazing combination of mind and body. As Professor of Medicine and Metabolism at Newcastle University, I’ve been fortunate to be able to find out what goes wrong to cause type 2 diabetes. It was not the complex mystery believed by other experts, but just one simple process. A little too much fat inside the liver caused insulin not to work properly, and an overspill of fat prevented enough insulin to be made. Growing a wild idea into a proven NHS programme involves sleepless nights, disbelief of colleagues, gratitude of patients, and hugely enjoyable team-working.
Where can you get reliable information on how the body works? Online sites are notoriously unreliable. Most textbooks are unreadable. But here is a book that explains clearly how the body uses food for fuel. This book is not an ‘easy read,’ so don’t curl up with it expecting instant enlightenment. However, if you want to learn the beautiful details of how your body works, go for it. The chapter on "Integration of carbohydrate, fat and protein metabolism in normal daily life" conveys an understanding of how food handling works, and just looking at the diagrams and graphs will take you a long way. And simply reading the "Key learning points" at the start of each chapter will introduce you to the magic of metabolism.
Metabolic Regulation looks in detail at how molecules, cells and tissues operate collectively in human health and disease, using an approach that has become known as 'integrative physiology'. Since the publication of the first edition of this extremely well received book, the understanding of how metabolism is regulated has developed substantially in several ways, for example with the discovery of the hormone leptin, and also in the continuing advances in the understanding of gene expression. Full details of these and other new advances are included in this fully updated edition. Carefully laid out with relevant and clearly explained examples, and…
Nature writer Sharman Apt Russell tells stories of her experiences tracking wildlife—mostly mammals, from mountain lions to pocket mice—near her home in New Mexico, with lessons that hold true across North America. She guides readers through the basics of identifying tracks and signs, revealing a landscape filled with the marks…
I’ve been reporting on and writing about food, eating, health, and body image for the last 25 years. So much of what we’re taught about those issues, it turns out, is wrong, inaccurate, and often damaging. I’ve made a point of uncovering the truth in those areas and to write about it in ways that help other people through this difficult terrain. My writing philosophy can be summed up in six words: I write so I’m not alone. And, I would add, so you’re not alone, either.
Though Linda Bacon didn’t originate the idea of Health at Every Size (HAES), this book popularized it for a mainstream audience. Here Bacon explains what HAES is and isn’t in clear, readable prose, supported by research, evidence, and logic. This book is a perfect starting point for anyone who wants to explore the ways we think about weight and health and how they are (and aren’t) connected.
Fat isn't the problem. Dieting is the problem. A society that rejects anyone whose body shape or size doesn't match an impossible ideal is the problem. A medical establishment that equates "thin" with "healthy" is the problem. The solution? Health at Every Size. Tune in to your body's expert guidance. Find the joy in movement. Eat what you want, when you want, choosing pleasurable foods that help you to feel good. You too can feel great in your body right now--and Health at Every Size will show you how. Health at Every Size has been scientifically proven to boost health…
Ever since I studied control theory as an undergrad chemical engineer, mathematical models of complex phenomena have fascinated me. Mathematical models have the uncanny ability to uncover key aspects of biological systems, whose complexity poses a great challenge for understanding. As a researcher in systems biology for over 15 years, I have enjoyed reading several books that explore the exciting interface between computation and biology, trying to capture the burgeoning literature on this rapidly advancing field. I hope you enjoy these books and will join these authors on an exciting journey into the cartography of molecular networks underlying every living cell, using a variety of mathematical models!
An outstanding and authoritative reference on metabolic networks. Discusses all the mathematical foundations of constraint-based methods, followed by detailed discussions of various constraint-based modelling methods. Despite the age, this remains a thorough and excellent account of constraint-based modelling. A revised second edition of this book presents a more detailed overview of metabolic networks in different organisms and is up-to-date with several advances in the field. Palsson is one of the leaders in the field of systems biology and metabolic networks, and his lab is home to many of the most important constraint-based modelling methods, such as flux balance analysis.
Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of…
Ever since I studied control theory as an undergrad chemical engineer, mathematical models of complex phenomena have fascinated me. Mathematical models have the uncanny ability to uncover key aspects of biological systems, whose complexity poses a great challenge for understanding. As a researcher in systems biology for over 15 years, I have enjoyed reading several books that explore the exciting interface between computation and biology, trying to capture the burgeoning literature on this rapidly advancing field. I hope you enjoy these books and will join these authors on an exciting journey into the cartography of molecular networks underlying every living cell, using a variety of mathematical models!
A very useful reference on systems biology, a sort of handbook, that provides a lot of breadth on systems biology topics. A unique aspect of this book is a set of chapters, introducing basic biology, mathematical techniques, experimental techniques, and a somewhat elaborate collection of databases/tools. Also includes material on stochastic modelling of biochemical reaction systems.
This advanced textbook is tailored to the needs of introductory course in Systems Biology. It has a compagnion website (WWW.WILEY-VCH.DE/HOME/SYSTEMSBIOLOGY) with solutions to questions in the book and several additional extensive working models. The book is related to the very successful previous title 'Systems Biology in Practice' and has incorporated the feedback and suggestions from many lecturers worldwide. The book addresses biologists as well as engineers and computer scientists. The interdisciplinary team of acclaimed authors worked closely together to ensure a comprehensive coverage with no overlaps in a homogenous and compelling style.
Citizen Scientist begins with this extraordinary statement by the Keeper of Entomology at the London Museum of Natural History, “Study any obscure insect for a week and you will then know more than anyone else on the planet.”
As the author chases the obscure Western red-bellied tiger beetle across New…
Ever since I studied control theory as an undergrad chemical engineer, mathematical models of complex phenomena have fascinated me. Mathematical models have the uncanny ability to uncover key aspects of biological systems, whose complexity poses a great challenge for understanding. As a researcher in systems biology for over 15 years, I have enjoyed reading several books that explore the exciting interface between computation and biology, trying to capture the burgeoning literature on this rapidly advancing field. I hope you enjoy these books and will join these authors on an exciting journey into the cartography of molecular networks underlying every living cell, using a variety of mathematical models!
One of the best broad-based textbooks covering a wide gamut of topics, and in-depth coverage of dynamic models. I like this book for a particularly engaging introduction to the practice of mathematical modelling, excellent catchy illustrations, and nice exercise problems/reading material at the end of each chapter. The book chooses to organise the methods by the type of network (gene systems, protein systems, metabolic systems, and so on). Voit is a very accomplished researcher in the area of dynamic systems modelling and is particularly known for his contributions to Biochemical Systems Theory.
A First Course in Systems Biology is a textbook designed for advanced undergraduate and graduate students. Its main focus is the development of computational models and their applications to diverse biological systems.
Because the biological sciences have become so complex that no individual can acquire complete knowledge in any given area of specialization, the education of future systems biologists must instead develop a student's ability to retrieve, reformat, merge, and interpret complex biological information.
This book provides the reader with the background and mastery of methods to execute standard systems biology tasks, understand the modern literature, and launch into specialized…
