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Shep Siegel conducted ingenious experiments in the 1970s demonstrating that drug tolerance in rats is largely if not entirely due to Pavlovian conditioning: The experienced drug user responds to indicators that a dose is imminent with physiological counter-responses that lessen the impact of the drug. Almost from the get-go, Siegel saw the potential relevance of his research to aspects of addiction, withdrawal, and relapse in human beings, but it has taken addiction researchers decades to assimilate the implications, which are profound.
Now retired, Siegel has written a highly readable retrospective account of this story which I found utterly convincing, and it should turn on light-switches in the head of anyone who has ever dealt with addiction, whether mild or severe, in one's self or in a family member or friend.
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1 author picked The Ghost in the Addict as one of their favorite books, and they share why you should read it.
How withdrawal distress and cravings can haunt current and former addicts, and what they can teach us about addiction and its treatments.
“The dead drug leaves a ghost behind. At certain hours it haunts the house,” Jean Cocteau once wrote. In The Ghost in the Addict, Shepard Siegel offers a Pavlovian analysis of drug use. Chronic drug use, he explains, conditions users to have an anticipatory homeostatic correction, which protects the addict from overdose. This drug-preparatory response, elicited by drug-paired cues, is often mislabeled a “withdrawal response.” The withdrawal response, however, is not due to the baneful effects of previous…
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