100 books like The Mutant Project

A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).

The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.

Somewhat paradoxically, this treatise against genetic enhancement starts with the case of a deaf couple who want to have a deaf child.

This is a case I often discuss in exploring the difference between disease, disability, and diversity. Following on from this case description, Sandel asks, “Is it wrong to make a child deaf by design?” And what if the desired trait was not deafness but height, athletic prowess, health, or intelligence, and the aim was to gain a competitive advantage?

Would your answer be the same? In the pages that follow, Sandel builds a case against “reengineering our nature” grounded in an ethic of giftedness (i.e., a reverence for life as a gift).

He eschews the drive to mastery and insists that “[t]o appreciate children as gifts is to accept them as they come, not as objects of our design, or products of our will, or instruments of our… show more.

This work of fiction highlights the potential dangers of genetic engineering.

It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.

In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.

Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer. 

Many assert that “science is outpacing ethics.”

In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”

In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.

He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.

When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.

The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.

Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative. 

We meet Phoenix, a woman grown in New York's Tower 7.

Even though she's only two years old, she has the mind and body of an adult, along with superhuman abilities. The death of her lover under dubious circumstances proves that Tower 7 is less of a home and more of a prison for Phoenix. She escapes to Ghana, where she learns brutal truths about colonialism and vows to fight back. Phoenix's fight for justice is electrifying.

I thoroughly enjoyed reading nine of Westerman's books, some of them twice. This is literary contemporary history. Aside from a place, a period, and a prism through which to look, Frank combines award-winning literary skills with a journalistic journey. His stories are both big and small, personal and universal. Here he follows a fascinating 20th-century journey of the so-called ‘most pure’ horses of Europe. Through that story, you will find yourself cantering through the nature versus nurture debate that defined much of Europe’s recent history. On top of all that, I also recognise his journey through life, from his studies to ‘development’ work to foreign journalism to literary non-fiction writing on the big issues at the people & places interface. 

Butler is known for bringing a black, feminist, and queer perspective to science fiction, a genre of futuristic and outer-space storytelling that traditionally features white male protagonists.

But what really captivates me about this book, which is set in a post-apocalyptic future where human survivors are mated with their alien rescuers (really!), is the way it asks icky-yet-intensely-meaningful questions. What does it mean to “be human” in a future of genetic hybridity and gender fluidity? What does it mean to love a partner or children whose genetics and culture are radically different from your own? When is violence futile, and when is it the only way to be heard?

I’m pretty much obsessed with this book, and I promise that any reader who has thought deeply about what it means to be really different will love it too.

This one is totally different than the others on my list, but when I was diving into these related genres and finding myself more and more inspired by them, it was always a surprise and a treat to find a book that just completely defied all genre expectations. The book blends Sci-Fi with Fantasy, something I’ve always enjoyed if done well, and something that made me think maybe I could try my hand at this. I was never that great in science or math, even though I tried, but the idea that we could mix Sci-Fi with Fantasy, now that was intriguing. And throw in a little unexpected romance and I think you have a really well-rounded adventure. Humans are the root cause of the ending of the human race, so obviously humans have to undo what they’ve done, but your average person is just trying to survive the fallout.

This book left me questioning what it truly means to be human. From the moment Logan Ramsay was infected with a mysterious virus, I was captivated by Crouch’s exploration of genetic enhancement. As Logan's abilities expanded—making him smarter, stronger, and more detached—I was both fascinated and horrified.

The tension between his new capabilities and the erosion of his emotional connections made the ethical dilemmas even more poignant. Crouch’s vision of a world on the brink of extinction, with genetic upgrades as both a salvation and a curse, felt disturbingly real. This isn’t just a techno-thriller; it’s a profound examination of what we might sacrifice in the relentless pursuit of progress.