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Chasing My Cure: A Doctor's Race to Turn Hope into Action; A Memoir Paperback – January 26, 2021

4.8 4.8 out of 5 stars 658 ratings

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NATIONAL BESTSELLER • “An extraordinary memoir that belongs with Atul Gawande’s writings and When Breath Becomes Air.”—Adam Grant, New York Times bestselling author of Originals

When a young doctor is diagnosed with a rare disease, he spearheads the search for a cure—and becomes a champion for a new approach to medical research.

David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose.

Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. Realizing that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he looked for clues that could unlock a new treatment and reached out to other Castleman disease patients and physicians. Instead of waiting for the scientific stars to align, he would attempt to align them himself.

More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.
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From the Publisher

Angela Duckworth says, a page turning chronicle of living, nearly dying and discovering hope.
Kirkus Reviews says, a powerful personal chronicle of a doctor’s rush to find a cure for a disease

Editorial Reviews

Review

“An extraordinary memoir . . . It belongs with Atul Gawande’s writings and When Breath Becomes Air.”—Adam Grant, New York Times bestselling author of Originals

“Dr. Fajgenbaum tells his own remarkable story of fighting a mysterious, nearly fatal multisystem disease, and of his brilliant deduction that a long-known drug may be the cure.  This book—part detective story, part love story, part scientific quest—shows how one indefatigable physician can bring hope to patients who suffer from a rare disease.”
—Michael S. Brown, MD, recipient of the Nobel Prize in Medicine, 1985
  
“This is a remarkable and gripping story. Dr. Fajgenbaum’s description of his journey is a tale of courage, dedication, and brilliance that will enthrall and fascinate its readers.”
—Arthur H. Rubenstein, professor of medicine, Perelman School of Medicine, University of Pennsylvania

“Chasing My Cure is a medical thriller that grapples with penultimate stakes—real love, bedrock faith, and how we spend our time on earth. Fast-paced and achingly transparent, David Fajgenbaum's deeply thoughtful memoir will have you rethinking your life's priorities.”—Lynn Vincent, #1 New York Times bestselling co-author of Heaven is for Real and Indianapolis

Chasing My Cure is the riveting story of Dr. Fajgenbaum’s remarkable journey persevering through illness to medical discoveries and recovery. It is also a tribute to his rare spirit and intellect, the support of his family and friends, the power of modern science, and the role that patients can play to find new treatments.”—J. Larry Jameson MD, PhD, dean, Perelman School of Medicine, University of Pennsylvania
 
“This is a fascinating true-life story of a young doctor, stricken with a rare, life-threatening disease, who takes matters into his own hands and, with total focus, finds a cure. . . . An informative and inspiring read.”
—Andrew Weil, MD

“I was riveted from the very first to the very last page of this extraordinary story of life, assumed death, resilience, and hope. I am convinced that through his incredible journey, David Fajgenbaum has acquired ‘superpowers’ that will no doubt shape the lives of others.”
—Nicole Boice, founder Global Genes

Chasing My Cure is an extremely powerful story about turning fear into faith, and hope into action. David Fajgenbaum’s ferocious will to survive and his leadership in the face of his rare disease provides a model pathway for others searching for cures of their own to follow.”—Stephen Groft, Pharm.D., former director, Office of Rare Diseases Research, National Institutes of Health

“Moving . . . A powerful, highly personal chronicle of a doctor’s feverish rush to find a cure for the disease that afflicts him.”Kirkus Reviews

About the Author

David Fajgenbaum, MD, MBA, MSc, is a graduate of Georgetown University, the University of Oxford, the University of Pennsylvania, and the Wharton School. An assistant professor of medicine at the University of Pennsylvania and the associate director for the Orphan Disease Center, he is cofounder and executive director of the Castleman Disease Collaborative Network, as well as the cofounder of the National Students of Ailing Mothers and Fathers Support Network. Dr. Fajgenbaum has been recognized with multiple awards, including the Forbes “30 Under 30” for healthcare and the RARE Champion of Hope Award for science. He has been profiled by major media outlets such as The New York Times, Forbes, Science, Reader’s Digest, and the Today show. He lives in Philadelphia with his wife, Caitlin, and their daughter, Amelia.

Product details

  • Publisher ‏ : ‎ Ballantine Books (January 26, 2021)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 256 pages
  • ISBN-10 ‏ : ‎ 1524799637
  • ISBN-13 ‏ : ‎ 978-1524799632
  • Item Weight ‏ : ‎ 2.31 pounds
  • Dimensions ‏ : ‎ 5.2 x 0.6 x 8 inches
  • Customer Reviews:
    4.8 4.8 out of 5 stars 658 ratings

About the author

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David Fajgenbaum
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David Fajgenbaum, MD, MBA, MSc is a groundbreaking physician-scientist, disease hunter, and bestselling author of the acclaimed memoir, Chasing My Cure: A Doctor's Race to Turn Hope Into Action. Fajgenbaum went from being a beast-like college Quarterback to receiving his last rites while in medical school and nearly dying four more times battling Castleman disease. To try to save his own life, he spearheaded an innovative approach to research and discovered a possible treatment that has put him into an extended remission. Now, he is spreading this approach to advance cures for other diseases and sharing lessons he learned about living from nearly dying through Chasing My Cure.

One of the youngest individuals ever appointed to the faculty at Penn Medicine and the top 1 percent youngest grant awardees of a leading NIH grant, Dr. Fajgenbaum is co-founder and executive director of the Castleman Disease Collaborative Network (CDCN) and Associate Director, Patient Impact, for the Penn Orphan Disease Center. He has been recognized on the Forbes 30 Under 30 list, as a top healthcare leader by Becker's Hospital Review, the Global Genes RARE Champion of Hope: Science awardee, and one of three recipients--including Vice President Joe Biden--of a 2016 Atlas Award from the World Affairs Council of Philadelphia. Before co-founding the CDCN, Dr. Fajgenbaum co-founded and led the Actively Moving Forward Support Network, a non-profit organization dedicated to supporting grieving college students. Dr. Fajgenbaum has been profiled in a cover story by The New York Times as well as by Good Morning America, CNN, and the Today Show, among others.

Dr. Fajgenbaum earned a BS from Georgetown University magna cum laude with honors and distinction, MSc from the University of Oxford, MD from the University of Pennsylvania Medical School, and MBA from The Wharton School. He is a former Division I college quarterback, state-champion weight lifter, and co-founder of a national grief support network.

Facebook.com/davidfajgenbaum or fb.me/davidfajgenbaum

Twitter: @DavidFajgenbaum

Customer reviews

4.8 out of 5 stars
658 global ratings

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Customers say

Customers find the story inspiring and riveting. They describe the book as an amazing, well-written read that provides solid medical information in a layman's language. Readers praise the author as honest and passionate, making it a must-read for healthcare heroes. The book is described as moving and impossible to put down once you start reading.

AI-generated from the text of customer reviews

40 customers mention "Inspirational story"40 positive0 negative

Customers find the story inspiring and engaging. It's a well-written account of one doctor's journey into the mystery of cancer. Readers appreciate the author's personal grit, love, and ingenuity. They feel motivated after reading it and consider it a guide to becoming their greatest self in any aspect of life.

"...- this book is an amazing read and Dr. Fajgenbaum is a true inspiration for persistence, strength, compassion, and determination." Read more

"...I love the day to day honesty of the author, so much drive and passion to find a cure for himself and others...." Read more

"...It is scientific and poetic, a mystery and a love story, and a story of near defeat and ultimate triumph all at the same time...." Read more

"...patient at one point in time myself, this book provides me tremendous inspiration to discover new drug candidates for patients whose lives are so..." Read more

39 customers mention "Readability"39 positive0 negative

Customers find the book engaging and well-written. They describe it as a must-read for ambitious people. The story is compelling and brave, dealing with loss and hardship in a meaningful way.

"...right - we do have a lot in common but seriously - this book is an amazing read and Dr. Fajgenbaum is a true inspiration for persistence, strength,..." Read more

"...A great read if you have a loved one and you want to understand more about it." Read more

"“Chasing my Cure” is one of the best books I’ve ever read. It is a story that will stay with you and fundamentally change the way you view the world...." Read more

"Bestseller! A must read" Read more

20 customers mention "Information quality"20 positive0 negative

Customers find the book informative and helpful for understanding medical science. It provides a clear explanation of complex biochemistry and immunology concepts in a relatable way. Readers describe it as an important read for anyone working in science, healthcare, or biotech. The story is described as poetic, a mystery, and a love story, with themes of determination and inquiry.

"...is a true inspiration for persistence, strength, compassion, and determination." Read more

"...It is scientific and poetic, a mystery and a love story, and a story of near defeat and ultimate triumph all at the same time...." Read more

"...is about a doctor who shares his journey to diagnosis and treatment of Castleman's Disease. Very good read...read it in one day...." Read more

"...this disease, this book is both a personal story and a resource for much needed understand and information about current treatment and research...." Read more

15 customers mention "Writing quality"15 positive0 negative

Customers appreciate the writing quality of the book. They find it well-written, honest, and a quick read. The author's passion and intelligence shine through in the writing.

"...Beautifully written - I literally could not put it down. I have told every friend and family member I know to read it, and you should as well...." Read more

"...other rare disease research, or those simply looking for a well-written inspiring memoir about a young physician whose greatest accomplishments I'm..." Read more

"...Moving story and well written, definitely recommend." Read more

"...Well written to be sure but the true tale is one that kept me captivated throughout...." Read more

12 customers mention "Human content"12 positive0 negative

Customers find the book's content human and inspiring. They describe it as a true story about a doctor-patient who fought to get a diagnosis and his own cure. The author's honesty and drive are appreciated.

"...I love the day to day honesty of the author, so much drive and passion to find a cure for himself and others...." Read more

"...discovery of an effective, already marketed drug, reads as a medical mystery book, that is in fact, completely factual...." Read more

"A must read for healthcare heroes" Read more

"...What an incredible story. What an incredible journey. What an incredible person. WOW!..." Read more

6 customers mention "Pacing"6 positive0 negative

Customers enjoy the book's pacing. They find it engaging and hard to put down once they start reading. The memoir is described as well-written and moving.

"...The book is a perfectly written memoir that is impossible to put down once you start...." Read more

"Great book couldn’t put it down. True story about a Doctor:patient who fought to get a diagnosis and his own cure !!!" Read more

"This book is can't-put-it-down good! I read it in an afternoon; truly fascinating." Read more

"A beautifully-written, moving, and at times humorous page-turning chronicle of Dr. Fajgenbaum's life..." Read more

Recommend
5 out of 5 stars
Recommend
‘Chasing My Cure’ is a memoir of Dr. David Fajgenbaum who after years of being top of his game both mentally and physically was hit by a crushing disease that took months to diagnose and almost killed him.Quarterback in Divison 1 Football and premed at Georgetown University and nicknamed ’The Beast’ Dr. Fajgenbaum watched his organs fail, his body bloat, and his doctors confused and unsure how to help. Finally diagnosed with the rare disease, Castleman syndrome, and ‘cured’ with chemotherapy he went back to life as a pre-med student only to see at least 5 more relapses.Dr. Fajgenbaum didn’t quit when the drugs stopped working - he researched, connected the individual doctors and researchers for Castleman’s syndrome around the world, and together found a medication that has kept him in remission to allow him to finish his medical training and start his family with the love of his life.When does the movie come out?My Mom sent me a cut out clipping from Reader’s Digest about Dr. Fajgenbaum (isn’t she the cutest) because we have so much in common:Undergrad at GeorgetownDivision I athletes (I played field hockey)Pre-med then medical schoolWe both lost parents in college - Dr. Fajgenbaum’s mother died of brain cancer and my father died of a heart attack - Dr. F started AMF - a support group for children that lose parents in college that is now a national group with chapter in colleges across the US (I graduated many years before David was at Georgetown and I wish I had this group when my father died)We’re both authors and passionate about our respective fields of medicineMy Mom was right - we do have a lot in common but seriously - this book is an amazing read and Dr. Fajgenbaum is a true inspiration for persistence, strength, compassion, and determination.
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Top reviews from the United States

  • Reviewed in the United States on July 13, 2020
    ‘Chasing My Cure’ is a memoir of Dr. David Fajgenbaum who after years of being top of his game both mentally and physically was hit by a crushing disease that took months to diagnose and almost killed him.
    Quarterback in Divison 1 Football and premed at Georgetown University and nicknamed ’The Beast’ Dr. Fajgenbaum watched his organs fail, his body bloat, and his doctors confused and unsure how to help. Finally diagnosed with the rare disease, Castleman syndrome, and ‘cured’ with chemotherapy he went back to life as a pre-med student only to see at least 5 more relapses.
    Dr. Fajgenbaum didn’t quit when the drugs stopped working - he researched, connected the individual doctors and researchers for Castleman’s syndrome around the world, and together found a medication that has kept him in remission to allow him to finish his medical training and start his family with the love of his life.
    When does the movie come out?
    My Mom sent me a cut out clipping from Reader’s Digest about Dr. Fajgenbaum (isn’t she the cutest) because we have so much in common:
    Undergrad at Georgetown
    Division I athletes (I played field hockey)
    Pre-med then medical school
    We both lost parents in college - Dr. Fajgenbaum’s mother died of brain cancer and my father died of a heart attack - Dr. F started AMF - a support group for children that lose parents in college that is now a national group with chapter in colleges across the US (I graduated many years before David was at Georgetown and I wish I had this group when my father died)
    We’re both authors and passionate about our respective fields of medicine
    My Mom was right - we do have a lot in common but seriously - this book is an amazing read and Dr. Fajgenbaum is a true inspiration for persistence, strength, compassion, and determination.
    Customer image
    5.0 out of 5 stars Recommend
    Reviewed in the United States on July 13, 2020
    ‘Chasing My Cure’ is a memoir of Dr. David Fajgenbaum who after years of being top of his game both mentally and physically was hit by a crushing disease that took months to diagnose and almost killed him.
    Quarterback in Divison 1 Football and premed at Georgetown University and nicknamed ’The Beast’ Dr. Fajgenbaum watched his organs fail, his body bloat, and his doctors confused and unsure how to help. Finally diagnosed with the rare disease, Castleman syndrome, and ‘cured’ with chemotherapy he went back to life as a pre-med student only to see at least 5 more relapses.
    Dr. Fajgenbaum didn’t quit when the drugs stopped working - he researched, connected the individual doctors and researchers for Castleman’s syndrome around the world, and together found a medication that has kept him in remission to allow him to finish his medical training and start his family with the love of his life.
    When does the movie come out?
    My Mom sent me a cut out clipping from Reader’s Digest about Dr. Fajgenbaum (isn’t she the cutest) because we have so much in common:
    Undergrad at Georgetown
    Division I athletes (I played field hockey)
    Pre-med then medical school
    We both lost parents in college - Dr. Fajgenbaum’s mother died of brain cancer and my father died of a heart attack - Dr. F started AMF - a support group for children that lose parents in college that is now a national group with chapter in colleges across the US (I graduated many years before David was at Georgetown and I wish I had this group when my father died)
    We’re both authors and passionate about our respective fields of medicine
    My Mom was right - we do have a lot in common but seriously - this book is an amazing read and Dr. Fajgenbaum is a true inspiration for persistence, strength, compassion, and determination.
    Images in this review
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    6 people found this helpful
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  • Reviewed in the United States on March 4, 2020
    When someone you love becomes deathly ill you get scared and seek answers. When those answers finally come , and you find out they have two rare diseases Castlemens and Poems you start your journey for answers and treatment. I was telling a doctor I work with and her eyes got big and she said I just read a book about that. So I bought the book plus copies for other family members. I love the day to day honesty of the author, so much drive and passion to find a cure for himself and others. The medical information and journey is intriguing and the hope it gives at the end gave me hope ! A great read if you have a loved one and you want to understand more about it.
    One person found this helpful
    Report
  • Reviewed in the United States on October 7, 2019
    “Chasing my Cure” is one of the best books I’ve ever read. It is a story that will stay with you and fundamentally change the way you view the world. It is scientific and poetic, a mystery and a love story, and a story of near defeat and ultimate triumph all at the same time. Beautifully written - I literally could not put it down. I have told every friend and family member I know to read it, and you should as well. David is destined to change the world and the telling of his story in his terrific book is the beginning. Accurately described as in the same league as “When Breath Becomes Air.”
    7 people found this helpful
    Report
  • Reviewed in the United States on September 10, 2019
    When I finally started to read Chasing My Cure, by author and doctor David Fajgenbaum, I had decided I wasn't going to like it. It was going to be boring and I wondered why had I requested it. I read a little and then I read a little bit more and I just kept reading. It was fascinating and should not have been placed in the same category as Atul Gawande's Being Mortal or Paul Kalanithi's When Breath Becomes Air. Fajgenbaum's moving chronicle to find a cure for his own sickness before it kills him is written with a sense of urgency, deep emotion and not even a tinge of self-pity. He writes with an earnestness and frankness about both the humility one must accept as a patient and healer with a mysterious, possibly deadly malady. The doctor offers his readers an uncommon perspective on disease and doctoring.
    Fajgenbaum's story is unusual but not unheard of in a world of people being diagnosed with diseases that have no cure. He was a former Georgetown quarterback, nicknamed the Beast, in medical school where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for the equivalent of a game day overtime: a second chance.
    His mother died of brain cancer while he was still in college and he vowed to become a doctor to fight cancer. When his own illness was diagnosed he ended up becoming the doctor to take on his own rare disease. Miraculously, Fajgenbaum survived.  Did he have cancer? No. The near-death relapses repeated themselves from what would eventually be identified as a form of Castleman's Disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder.
    The only drug available didn't work and David suffered 4 more agonizing relapses moving so near death he was given last rites.  He struggled with the realization that any further medical breakthrough was unlikely to happen in time to save his life.
    Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. He also reached out to other Castleman's Disease patients and physicians and eventually came up with an ambitious plan to take advantage of the most promising research and world-class researchers to tackle the disease.

    It took five years for Fajgenbaum to see his hard work pay off. A treatment that he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research, crowdsourcing. His incredible story demonstrates the power of hope, and what can happen when the forces of determination, family and faith all come together.
    The one weakness of the book is the writing. Fajgenbaum weaves a fascinating and important story but his words are often dry and dull. Both Fajgenbaum and the people who support him are just dry. It takes effort and skill to unlock even the most elementary narrative and in the hands of this immature but well-intentioned writer, Chasing My Cure falls short.
    Chasing My Cure is part detective story and part scientific quest. It's the mystery of what was happening in his own body and he uses his own experience to explain the incredible shortcomings of modern medicine. Fajgenbaum makes a compelling case for creating a new model of research and treatment, to break out of the silos of modern medicine. He shows a way to look for common ground across many different kinds of diseases, to be more innovative and nimble in the search for a cure.
    In the course of his research, Fajgenbaum established the Castleman’s Disease Collaborative Network. His organization has changed the way rare disease research and funding is handled. “I became invincible in hope only after I realized I was called to act …on my hope.”
    15 people found this helpful
    Report
  • Reviewed in the United States on November 27, 2024
    Bestseller! A must read

Top reviews from other countries

  • Kirsten
    5.0 out of 5 stars Very pleased with ordering from this bookseller!
    Reviewed in Canada on October 22, 2023
    Very pleased with this book, and would definitely order from this seller again. I'm in Canada, they are in US, didn't take long at all, thank you!
  • Paul C
    5.0 out of 5 stars A Castleman Disease eye opener.
    Reviewed in the United Kingdom on January 17, 2025
    Well worth reading if you, or a loved one is diagnosed with iMCD.
  • sumithra
    5.0 out of 5 stars Inspiring and Emotional read
    Reviewed in India on December 30, 2024
    From the lens of a patient (who is also a doctor) battling with a life threatening disease. The journey of fear, vulnerability and search for the answers.
  • David G
    5.0 out of 5 stars Amazing book
    Reviewed in Spain on June 28, 2023
    Amazong book that describes very well David’s journey.
    Thanks David for sharing your story.
  • Gregory M Reid
    5.0 out of 5 stars A great read for anyone with immune system related disorders.
    Reviewed in Canada on June 6, 2022
    I heard the author in a radio interview 2 years after I had been diagnosed with Poly Myalgia Rheumatica (PMR), an immune related arthritic condition which had left me bedridden from time to time, and in constant pain most of the rest of the time. At the time I ordered the book, I had been prescribed numerous combinations of steroids and immune-suppressing drugs, none of which gave me complete relief, and the side effects were very harsh and concerning.
    After reading this book (an easy read - the author has a talent for explaining very technical info in an interesting and easily understood format), I did some research on biologic class medications, and pressed my rheumatologist for solutions other than what I had been previously prescribed.
    I am now taking a biologic mentioned in the book (Tocilizumab - "Actemra") that has completely controlled my condition, with no apparent side effects - I am back to unlimited exercising, and the active lifestyle I enjoyed before being diagnosed.
    The book describes an incredible journey through the unknown for the author, having been diagnosed with a rare immune disease with no known cure that threatened to end his life several times, and the "out of the box" steps he took to solve his own dilemma. His efforts to save his own life, and give hope to others are truly heroic.