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So Simple a Beginning: How Four Physical Principles Shape Our Living World Hardcover – February 8, 2022

4.5 4.5 out of 5 stars 35 ratings

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A biophysicist reveals the hidden unity behind nature’s breathtaking complexity

The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it.
So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.

Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound.

Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.

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Editorial Reviews

Review

"Hands down the most beautiful book I’ve ever read. . . . The intersection of biology and physics might be the most underappreciated cross-over in the sciences."---Nicole Barbaro, Bookmarked

"The author's style is mostly captivating, and the illustrations provide unique support . . . Parthasarathy's commitment regarding the importance of education about scientific discovery and its place in today's world is evident throughout."
---F. W. Yow, Choice

Review

“Deft and engaging. Parthasarathy constantly finds the metaphors that best illuminate his subject. And what a subject—a perfect mix of the latest exciting new work with classic results needed to understand it. Every chapter gives an original view from a wide-ranging intellect, and unifies ideas that are rarely presented together.”—Philip Nelson, author of From Photon to Neuron: Light, Imaging, Vision

“Parthasarathy presents an accessible yet scientifically accurate picture of modern biology, and it’s a pleasure to read.”
—Sonia Contera, author of Nano Comes to Life

“Parthasarathy has given readers a delightful narrative guide to the exciting and important ways in which physics and biology come together to help us understand living matter. I found myself learning something new in every chapter and loved the fun case studies, constant insights, and captivating illustrations.”
—Rob Phillips, author of The Molecular Switch: Signaling and Allostery

Product details

  • Publisher ‏ : ‎ Princeton University Press (February 8, 2022)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 336 pages
  • ISBN-10 ‏ : ‎ 0691200408
  • ISBN-13 ‏ : ‎ 978-0691200408
  • Item Weight ‏ : ‎ 1.5 pounds
  • Dimensions ‏ : ‎ 6.5 x 1.25 x 9.5 inches
  • Customer Reviews:
    4.5 4.5 out of 5 stars 35 ratings

About the author

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Raghuveer Parthasarathy
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Raghuveer Parthasarathy has been a Physics professor at the University of Oregon since 2006. His research interests involve biophysics, especially the structure and dynamics of the gut microbiome, which his research group explores using new sorts of optical microscopy. He is a Fellow of the American Physical Society. His teaching interests mostly involve courses for non-science majors, including a “biophysics for non-scientists” class (The Physics of Life) and "Physics of Energy and the Environment."

He has written and illustrated a popular-science book on biophysics, "So Simple a Beginning: How Four Physical Principles Shape Our Living World," available in early 2022.

Customer reviews

4.5 out of 5 stars
4.5 out of 5
35 global ratings

Top reviews from the United States

Reviewed in the United States on April 9, 2024
His style is relatable and engaging. I like that he frequently sums things up before moving on. He makes difficult content understandable in principle. I thoroughly enjoyed it.
Reviewed in the United States on May 4, 2022
This book has left me speechless. I've never come across a non-fiction book, let alone pop sci book that is so elegant, lucid, and above all so informative. The author's passion for his subject is virtually tangible in every page, and by the end, you have a completely new perspective of science and the world around you.

The author is so good at explaining certain ideas , such as the random motion of matter, some of which are actually very complex. What's unique about Parthasarathy is that he isn't afraid to go into the technical details of his subject, but he does so while preserving the accessibility of the book. The problem with many pop sci books these days is that the authors oversimplify the material, which can in many cases serve to obscure rather than clarify. In this book, almost every idea, regardless of its complexity, is supplemented with ample explanation such that the reader can at the very least come way with a high-level understanding of it. There are also many beautiful illustrations that facilitate comprehension.

Regarding the ideas themselves, the book is about biophysics, which is rarely communicated to a general audience. Since this field is at the intersection of biology and physics, it can give us unique insights into living systems, the properties of which can't all be explained by some of the standard concepts in biology(evolution, etc). One of the points of the book, as mentioned in it, is to show how the physical laws manifest themselves in living systems, which can explain how living things assemble, their function, form, and etc.

Overall, this book is one of a kind. In fact, it is one of the best pop sci books ever written, and should be read widely.
19 people found this helpful
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Reviewed in the United States on October 31, 2023
Forget all the trendy biology books. This book has a cohesive theme, elegant clear writing style and wonderful graphics. The themes: 1. nature undergoes natural self-organization. 2. complex systems involve regulatory networks. 3. predictable randomness.( here his physics background was illuminating)
4. scalability. Once again his physics background gave me much to think about. I am about to read it again! It is a treasure. Compared to many arrogant know it alls in the field of science writing, his was a voice of modesty, inquisitiveness and wisdom.
Reviewed in the United States on March 9, 2022
The chapters on embryos, organs, the microbiome, and scaling are particularly fresh, insightful, and beautifully clear. Also, unlike so many popularizations, this one is full of graceful graphics that actually clarify key points -- not just eye candy.

Parthasarathy respects the reader too much to give a jumble of just-so stories wrapped in a few human interest stories. Instead he explains, often with brilliant metaphors to everyday experience. Any aspiring science student, and really most specialists, will benefit immensely from this book.
17 people found this helpful
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Reviewed in the United States on March 17, 2022
This effort advances a great tradition of leading thinkers with top notch training in physics - think likes of Schrodinger, Penrose - explaining fundamental questions of life holistically.

Hand drawn pictures are awesome.
8 people found this helpful
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Reviewed in the United States on March 2, 2022
Dr. Parthasarathy has written a wonderful science book. In my opinion, it stands apart from many popular physics books, in that it does not talk down to readers. The physics is deep and surprising, yet also clearly articulated. The author obviously has a very deep knowledge of his subject, and he has brought it to life in remarkable way.

As an undergraduate I studied biophysics down the hall from Dr. Parthasarathy at the University of Oregon, and I still learned very many things from this book. I highly recommend it!
12 people found this helpful
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Reviewed in the United States on July 17, 2023
The book arrived with all kinds of smudges on the cover and the book sleeve was bent ant creased.
Reviewed in the United States on April 21, 2022
This is a delightful book by Raghu Parthasarathy. Living systems are different from inanimate matter, yet are governed by the same laws of physics. Here Raghu takes us through a breathtaking journey of the variety and grandeur of life with an emphasis on striking commonalities and an underlying simplicity. The illustrations of this very talented author are worthy of celebration.
7 people found this helpful
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